Self-assembly and Self-replication of Short Amphiphilic β-sheet Peptides

Valery Bourbo, Maayan Matmor, Elina Shtelman, Boris Rubinov, Nurit Ashkenasy, Gonen Ashkenasy

Research output: Contribution to journalArticlepeer-review


Most self-replicating peptide systems are made of α-helix forming sequences. However, it has been postulated that shorter and simpler peptides may also serve as templates for replication when arranged into well-defined structures. We describe here the design and characterization of new peptides that form soluble β-sheet aggregates that serve to significantly accelerate their ligation and self-replication. We then discuss the relevance of these phenomena to early molecular evolution, in light of additional functionality associated with β-sheet assemblies.

Original languageAmerican English
Pages (from-to)563-567
Number of pages5
JournalOrigins of Life and Evolution of Biospheres
Issue number6
StatePublished - 1 Dec 2011


  • Prebiotic peptides
  • Self-replication
  • β-sheets

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Space and Planetary Science


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