Selective Persulfide Detection Reveals Evolutionarily Conserved Antiaging Effects of S-Sulfhydration

Jasmina Zivanovic; Emilia Kouroussis; Joshua B. Kohl; Bikash Adhikari; Biljana Bursac; Sonia Schott-Roux; Dunja Petrovic; Jan Lj Miljkovic; Daniel Thomas-Lopez; Youngeun Jung; Marko Miler; Sarah Mitchell; Verica Milosevic; Jose Eduardo Gomes; Moran Benhar; Bruno Gonzales-Zorn; Ivana Ivanovic-Burmazovic; Roberta Torregrossa; James R. Mitchell; Matthew Whiteman; Guenter Schwarz; Solomon H. Snyder; Bindu D. Paul; Kate S. Carroll; Milos R. Filipovic

doi:https://doi.org/10.1016/j.cmet.2019.10.007

Selective Persulfide Detection Reveals Evolutionarily Conserved Antiaging Effects of S-Sulfhydration

Jasmina Zivanovic, Emilia Kouroussis, Joshua B. Kohl, Bikash Adhikari, Biljana Bursac, Sonia Schott-Roux, Dunja Petrovic, Jan Lj Miljkovic, Daniel Thomas-Lopez, Youngeun Jung, Marko Miler, Sarah Mitchell, Verica Milosevic, Jose Eduardo Gomes, Moran Benhar, Bruno Gonzales-Zorn, Ivana Ivanovic-Burmazovic, Roberta Torregrossa, James R. Mitchell, Matthew WhitemanGuenter Schwarz, Solomon H. Snyder, Bindu D. Paul, Kate S. Carroll, Milos R. Filipovic

Medicine

Technion - Israel Institute of Technology

Research output: Contribution to journal › Article › peer-review

Abstract

Zivanovic et al. develop a robust method for chemoselective persulfide labeling using dimedone-based probes to show that persulfidation is an evolutionarily conserved post-translational modification used by the cells to protect proteins from overoxidation caused by different stressors. Higher persulfidation levels, caused by pharmacological or dietary interventions, lead to better resistance to oxidative stress and longer life.

Original language	English
Pages (from-to)	1152-1170.e13
Journal	Cell Metabolism
Volume	30
Issue number	6
DOIs	https://doi.org/10.1016/j.cmet.2019.10.007
State	Published - 3 Dec 2019

Keywords

aging
calorie restriction
hydrogen peroxide
hydrogen sulfide
protein persulfidation
redox signaling
sulfenylation
sulfinylation
sulfonylation

All Science Journal Classification (ASJC) codes

Physiology
Molecular Biology
Cell Biology

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https://doi.org/10.1016/j.cmet.2019.10.007

Cite this

Zivanovic, J., Kouroussis, E., Kohl, J. B., Adhikari, B., Bursac, B., Schott-Roux, S., Petrovic, D., Miljkovic, J. L., Thomas-Lopez, D., Jung, Y., Miler, M., Mitchell, S., Milosevic, V., Gomes, J. E., Benhar, M., Gonzales-Zorn, B., Ivanovic-Burmazovic, I., Torregrossa, R., Mitchell, J. R., ... Filipovic, M. R. (2019). Selective Persulfide Detection Reveals Evolutionarily Conserved Antiaging Effects of S-Sulfhydration. Cell Metabolism, 30(6), 1152-1170.e13. https://doi.org/10.1016/j.cmet.2019.10.007

@article{3e97c8fec291490b8dd0325545068f66,

title = "Selective Persulfide Detection Reveals Evolutionarily Conserved Antiaging Effects of S-Sulfhydration",

abstract = "Zivanovic et al. develop a robust method for chemoselective persulfide labeling using dimedone-based probes to show that persulfidation is an evolutionarily conserved post-translational modification used by the cells to protect proteins from overoxidation caused by different stressors. Higher persulfidation levels, caused by pharmacological or dietary interventions, lead to better resistance to oxidative stress and longer life.",

keywords = "aging, calorie restriction, hydrogen peroxide, hydrogen sulfide, protein persulfidation, redox signaling, sulfenylation, sulfinylation, sulfonylation",

author = "Jasmina Zivanovic and Emilia Kouroussis and Kohl, {Joshua B.} and Bikash Adhikari and Biljana Bursac and Sonia Schott-Roux and Dunja Petrovic and Miljkovic, {Jan Lj} and Daniel Thomas-Lopez and Youngeun Jung and Marko Miler and Sarah Mitchell and Verica Milosevic and Gomes, {Jose Eduardo} and Moran Benhar and Bruno Gonzales-Zorn and Ivana Ivanovic-Burmazovic and Roberta Torregrossa and Mitchell, {James R.} and Matthew Whiteman and Guenter Schwarz and Snyder, {Solomon H.} and Paul, {Bindu D.} and Carroll, {Kate S.} and Filipovic, {Milos R.}",

note = "Publisher Copyright: {\textcopyright} 2019",

year = "2019",

month = dec,

day = "3",

doi = "https://doi.org/10.1016/j.cmet.2019.10.007",

language = "الإنجليزيّة",

volume = "30",

pages = "1152--1170.e13",

journal = "Cell Metabolism",

issn = "1550-4131",

publisher = "Cell Press",

number = "6",

}

Zivanovic, J, Kouroussis, E, Kohl, JB, Adhikari, B, Bursac, B, Schott-Roux, S, Petrovic, D, Miljkovic, JL, Thomas-Lopez, D, Jung, Y, Miler, M, Mitchell, S, Milosevic, V, Gomes, JE, Benhar, M, Gonzales-Zorn, B, Ivanovic-Burmazovic, I, Torregrossa, R, Mitchell, JR, Whiteman, M, Schwarz, G, Snyder, SH, Paul, BD, Carroll, KS & Filipovic, MR 2019, 'Selective Persulfide Detection Reveals Evolutionarily Conserved Antiaging Effects of S-Sulfhydration', Cell Metabolism, vol. 30, no. 6, pp. 1152-1170.e13. https://doi.org/10.1016/j.cmet.2019.10.007

TY - JOUR

T1 - Selective Persulfide Detection Reveals Evolutionarily Conserved Antiaging Effects of S-Sulfhydration

AU - Zivanovic, Jasmina

AU - Kouroussis, Emilia

AU - Kohl, Joshua B.

AU - Adhikari, Bikash

AU - Bursac, Biljana

AU - Schott-Roux, Sonia

AU - Petrovic, Dunja

AU - Miljkovic, Jan Lj

AU - Thomas-Lopez, Daniel

AU - Jung, Youngeun

AU - Miler, Marko

AU - Mitchell, Sarah

AU - Milosevic, Verica

AU - Gomes, Jose Eduardo

AU - Benhar, Moran

AU - Gonzales-Zorn, Bruno

AU - Ivanovic-Burmazovic, Ivana

AU - Torregrossa, Roberta

AU - Mitchell, James R.

AU - Whiteman, Matthew

AU - Schwarz, Guenter

AU - Snyder, Solomon H.

AU - Paul, Bindu D.

AU - Carroll, Kate S.

AU - Filipovic, Milos R.

PY - 2019/12/3

Y1 - 2019/12/3

N2 - Zivanovic et al. develop a robust method for chemoselective persulfide labeling using dimedone-based probes to show that persulfidation is an evolutionarily conserved post-translational modification used by the cells to protect proteins from overoxidation caused by different stressors. Higher persulfidation levels, caused by pharmacological or dietary interventions, lead to better resistance to oxidative stress and longer life.

AB - Zivanovic et al. develop a robust method for chemoselective persulfide labeling using dimedone-based probes to show that persulfidation is an evolutionarily conserved post-translational modification used by the cells to protect proteins from overoxidation caused by different stressors. Higher persulfidation levels, caused by pharmacological or dietary interventions, lead to better resistance to oxidative stress and longer life.

KW - aging

KW - calorie restriction

KW - hydrogen peroxide

KW - hydrogen sulfide

KW - protein persulfidation

KW - redox signaling

KW - sulfenylation

KW - sulfinylation

KW - sulfonylation

UR - http://www.scopus.com/inward/record.url?scp=85075485979&partnerID=8YFLogxK

U2 - https://doi.org/10.1016/j.cmet.2019.10.007

DO - https://doi.org/10.1016/j.cmet.2019.10.007

M3 - مقالة

SN - 1550-4131

VL - 30

SP - 1152-1170.e13

JO - Cell Metabolism

JF - Cell Metabolism

IS - 6

ER -

Selective Persulfide Detection Reveals Evolutionarily Conserved Antiaging Effects of S-Sulfhydration

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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