Abstract
A diiodo ruthenium olefin metathesis pre-catalyst was employed to achieve remarkably selective cross-metathesis reactions of prenylated 1,6-dienes, effectively overcoming the entropically favored intramolecular ring-closing metathesis. This reaction was investigated using Density Functional Theory (DFT) computations and fine-tuned through the application of a Design of Experiments (DoE) approach. The potential of this innovative process was demonstrated through the unprecedented functionalization of various terpene natural products via cross-metathesis, resulting in the synthesis of new derivatives in a single step.
Original language | American English |
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Article number | e202412430 |
Journal | Angewandte Chemie - International Edition |
Volume | 63 |
Issue number | 52 |
DOIs | |
State | Published - 20 Dec 2024 |
Keywords
- cross-metathesis
- iodide ligands
- olefin metathesis
- sulfur-chelated ruthenium
- terpenes
All Science Journal Classification (ASJC) codes
- General Chemistry
- Catalysis