Selective autophagy bears bone

Milana Fraiberg; Zvulun Elazar

doi:10.15252/embj.2020105965

Selective autophagy bears bone

Milana Fraiberg, Zvulun Elazar

Department of Biomolecular Sciences

Weizmann Institute of Science

Research output: Contribution to journal › Article › peer-review

Abstract

The endoplasmic reticulum (ER) is a dynamic intracellular network responsible for folding and maturation of organellar and secreted proteins. Selective autophagy of ER (ER-phagy) is emerging as an essential process that maintains proteostasis in the ER and is regulated by growth conditions. In this issue, Cinque et al (2020) show that fibroblast growth factor 18 (FGF18) specifically activates ER-phagy through a TFEB/TFE-dependent transcriptional regulation of the ER-phagy receptor Fam134b, a process essential for bone ossification and skeletal development.

Original language	English
Article number	105965
Number of pages	2
Journal	EMBO Journal
Volume	39
Issue number	17
Early online date	27 Jul 2020
DOIs	https://doi.org/10.15252/embj.2020105965
State	Published - 1 Sep 2020

All Science Journal Classification (ASJC) codes

General Immunology and Microbiology
General Biochemistry,Genetics and Molecular Biology
Molecular Biology
General Neuroscience

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10.15252/embj.2020105965

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title = "Selective autophagy bears bone",

abstract = "The endoplasmic reticulum (ER) is a dynamic intracellular network responsible for folding and maturation of organellar and secreted proteins. Selective autophagy of ER (ER-phagy) is emerging as an essential process that maintains proteostasis in the ER and is regulated by growth conditions. In this issue, Cinque et al (2020) show that fibroblast growth factor 18 (FGF18) specifically activates ER-phagy through a TFEB/TFE-dependent transcriptional regulation of the ER-phagy receptor Fam134b, a process essential for bone ossification and skeletal development.",

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AB - The endoplasmic reticulum (ER) is a dynamic intracellular network responsible for folding and maturation of organellar and secreted proteins. Selective autophagy of ER (ER-phagy) is emerging as an essential process that maintains proteostasis in the ER and is regulated by growth conditions. In this issue, Cinque et al (2020) show that fibroblast growth factor 18 (FGF18) specifically activates ER-phagy through a TFEB/TFE-dependent transcriptional regulation of the ER-phagy receptor Fam134b, a process essential for bone ossification and skeletal development.

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Selective autophagy bears bone

Abstract

All Science Journal Classification (ASJC) codes

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