Scaling physiologic function from cell to tissue in asthma, cancer, and development

Yasha Sharma; Lior Atia; Christalyn Sims Rhodes; Stephen J. DeCamp; Jennifer Mitchel; Jeffrey J. Fredberg

doi:10.1513/AnnalsATS.201710-790KV

Scaling physiologic function from cell to tissue in asthma, cancer, and development

Yasha Sharma, Lior Atia, Christalyn Sims Rhodes, Stephen J. DeCamp, Jennifer Mitchel, Jeffrey J. Fredberg

Research output: Contribution to journal › Article › peer-review

Abstract

The formation of an integrated tissue from individual cells depends on the properties of the individual cells as well as the interaction of many cells acting as a collective. Three fundamental physiological processes govern the collective scaling from the individual cell to a working tissue: cell sorting, tissue assembly, and collective cellular migration. Mechanistically, cell sorting is governed by differential adhesion, whereas tissue assembly is controlled by the epithelial-tomesenchymal transition and its inverse, the mesenchymal-toepithelial transition. The mechanism driving collective cellular migration, however, is not clear. To fill that gap, here we consider cell jamming and unjamming, and their role in collective cellular migration.

Original language	American English
Pages (from-to)	S35-S37
Journal	Annals of the American Thoracic Society
Volume	15
DOIs	https://doi.org/10.1513/AnnalsATS.201710-790KV
State	Published - 1 Feb 2018
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Collective
Epithelium
Jamming
Migration

All Science Journal Classification (ASJC) codes

Pulmonary and Respiratory Medicine

Access to Document

10.1513/AnnalsATS.201710-790KV

Cite this

@article{7fb704c2d5c5407183bf3fd3b445a6ce,

title = "Scaling physiologic function from cell to tissue in asthma, cancer, and development",

abstract = "The formation of an integrated tissue from individual cells depends on the properties of the individual cells as well as the interaction of many cells acting as a collective. Three fundamental physiological processes govern the collective scaling from the individual cell to a working tissue: cell sorting, tissue assembly, and collective cellular migration. Mechanistically, cell sorting is governed by differential adhesion, whereas tissue assembly is controlled by the epithelial-tomesenchymal transition and its inverse, the mesenchymal-toepithelial transition. The mechanism driving collective cellular migration, however, is not clear. To fill that gap, here we consider cell jamming and unjamming, and their role in collective cellular migration.",

keywords = "Collective, Epithelium, Jamming, Migration",

author = "Yasha Sharma and Lior Atia and Rhodes, \{Christalyn Sims\} and DeCamp, \{Stephen J.\} and Jennifer Mitchel and Fredberg, \{Jeffrey J.\}",

note = "Publisher Copyright: Copyright {\textcopyright} 2018 by the American Thoracic Society.",

year = "2018",

month = feb,

day = "1",

doi = "10.1513/AnnalsATS.201710-790KV",

language = "American English",

volume = "15",

pages = "S35--S37",

journal = "Annals of the American Thoracic Society",

issn = "2325-6621",

publisher = "American Thoracic Society",

}

TY - JOUR

T1 - Scaling physiologic function from cell to tissue in asthma, cancer, and development

AU - Sharma, Yasha

AU - Atia, Lior

AU - Rhodes, Christalyn Sims

AU - DeCamp, Stephen J.

AU - Mitchel, Jennifer

AU - Fredberg, Jeffrey J.

PY - 2018/2/1

Y1 - 2018/2/1

N2 - The formation of an integrated tissue from individual cells depends on the properties of the individual cells as well as the interaction of many cells acting as a collective. Three fundamental physiological processes govern the collective scaling from the individual cell to a working tissue: cell sorting, tissue assembly, and collective cellular migration. Mechanistically, cell sorting is governed by differential adhesion, whereas tissue assembly is controlled by the epithelial-tomesenchymal transition and its inverse, the mesenchymal-toepithelial transition. The mechanism driving collective cellular migration, however, is not clear. To fill that gap, here we consider cell jamming and unjamming, and their role in collective cellular migration.

AB - The formation of an integrated tissue from individual cells depends on the properties of the individual cells as well as the interaction of many cells acting as a collective. Three fundamental physiological processes govern the collective scaling from the individual cell to a working tissue: cell sorting, tissue assembly, and collective cellular migration. Mechanistically, cell sorting is governed by differential adhesion, whereas tissue assembly is controlled by the epithelial-tomesenchymal transition and its inverse, the mesenchymal-toepithelial transition. The mechanism driving collective cellular migration, however, is not clear. To fill that gap, here we consider cell jamming and unjamming, and their role in collective cellular migration.

KW - Collective

KW - Epithelium

KW - Jamming

KW - Migration

UR - http://www.scopus.com/inward/record.url?scp=85045335309&partnerID=8YFLogxK

U2 - 10.1513/AnnalsATS.201710-790KV

DO - 10.1513/AnnalsATS.201710-790KV

M3 - Article

SN - 2325-6621

VL - 15

SP - S35-S37

JO - Annals of the American Thoracic Society

JF - Annals of the American Thoracic Society

ER -

Scaling physiologic function from cell to tissue in asthma, cancer, and development

Abstract

UN SDGs

Keywords

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this