Scaling of dorsal-ventral patterning in the Xenopus laevis embryo

Research output: Contribution to journalArticlepeer-review

Abstract

Scaling of pattern with size has been described and studied for over a century, yet its molecular basis is understood in only a few cases. In a recent, elegant study, Inomata and colleagues proposed a new model explaining how bone morphogenic protein (BMP) activity gradient scales with embryo size in the early Xenopus laevis embryo. We discuss their results in conjunction with an alternative model we proposed previously. The expansion-repression mechanism (ExR) provides a conceptual framework unifying both mechanisms. Results of Inomata and colleagues implicate the chordin-stabilizing protein sizzled as the expander molecule enabling scaling, while we attributed this role to the BMP ligand Admp. The two expanders may work in concert, as suggested by the mathematical model of Inomata et al. We discuss approaches for differentiating the contribution of sizzled and Admp to pattern scaling.

Original languageAmerican English
Pages (from-to)151-156
Number of pages6
JournalBioEssays
Volume36
Issue number2
DOIs
StatePublished - Feb 2014

Keywords

  • BMP
  • Development
  • Mathematical modeling
  • Morphogen gradient
  • Patterning
  • Scaling
  • Xenopus

All Science Journal Classification (ASJC) codes

  • General Biochemistry,Genetics and Molecular Biology

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