Abstract
We propose a new modeling approach for studying the effect of sarcomere non-uniformities on muscle function in a quantitative manner and for a physiologically relevant number of sarcomeres.
Based on this approach, force enhancement experiments are simulated, and demonstrate a very good agreement with experiments. In particular, we are able to show that if a physiologically relevant number of sarcomeres is considered, non-uniformities alone can lead to residual force enhancement on the ascending limb and to residual forces higher than the optimal force.
Based on this approach, force enhancement experiments are simulated, and demonstrate a very good agreement with experiments. In particular, we are able to show that if a physiologically relevant number of sarcomeres is considered, non-uniformities alone can lead to residual force enhancement on the ascending limb and to residual forces higher than the optimal force.
| Original language | American English |
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| Title of host publication | CMBE15 :4th International Conference on Computational & Mathematical Biomedical Engineering |
| Subtitle of host publication | 29th June - 1st July 2015 : ´ Ecole Normale Sup´erieure de Cachan : Cachan (Paris) France |
| Editors | Perumal Nithiarasu, Elisa Budyn |
| Pages | 749-752 |
| State | Published - 2015 |
| Event | 4th International Conference on Computational and Mathematical Biomedical Engineering, CMBE15 - Paris, France Duration: 29 Jun 2015 → 1 Jul 2015 |
Conference
| Conference | 4th International Conference on Computational and Mathematical Biomedical Engineering, CMBE15 |
|---|---|
| Abbreviated title | CMBE15 |
| Country/Territory | France |
| City | Paris |
| Period | 29/06/15 → 1/07/15 |