Salty and Sweet: Protein Glycosylation in Haloferax volcanii

Jerry Eichler, Doron Calo, Lina Kaminski, Lina Kandiba, Zvia Konrad, Hilla Magidovich, Shai Naparstek, Sophie Yurist-Doutsch

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Ever since the discovery of the first glycosylated archaeal protein, namely the Halobacterium salinarum surface-layer glycoprotein some 35 years ago, research on haloarchaea has been at the forefront of efforts to decipher the archaeal version of N-glycosylation, a universal post-translational modification. Now, with the availability of sufficient numbers of genome sequences and the development of appropriate experimental tools, the possibility for detailed molecular analysis of archaeal N-glycosylation pathways is being realized, using haloarchaeal species as model systems. In this chapter, current understanding of N-glycosylation in Archaea and the contribution of studies on Haloferax volcanii to such endeavors are described.
Original languageAmerican English
Title of host publicationHalophiles and Hypersaline Environments
EditorsA. Ventosa, A. Oren
PublisherSpringer Berlin
Number of pages9
ISBN (Electronic)978-3-642-20198-1
ISBN (Print)978-3-642-20197-4
StatePublished - 27 May 2011


  • Halobacterium salinarum
  • Halophilic Archaea
  • Hexuronic Acid
  • Protein Glycosylation
  • Sulfated Polysaccharide


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