@article{fa35a3912d714d38b847459ac4e21309,
title = "Role of m(6)A in Embryonic Stem Cell Differentiation and in Gametogenesis",
abstract = "The rising field of RNA modifications is stimulating massive research nowadays. m(6)A, the most abundant mRNA modification is highly conserved during evolution. Through the last decade, the essential components of this dynamic mRNA modification machinery were found and classified into writer, eraser and reader proteins. m(6)A modification is now known to take part in diverse biological processes such as embryonic development, cell circadian rhythms and cancer stem cell proliferation. In addition, there is already firm evidence for the importance of m(6)A modification in stem cell differentiation and gametogenesis, both in males and females. This review attempts to summarize the important results of recent years studying the mechanism underlying stem cell differentiation and gametogenesis processes.",
author = "Lior Lasman and Hanna, {Jacob H.} and Noa Novershtern",
note = "Author Contributions L.L. and N.N. wrote the review; with edits from J.H.H. All authors have read and agreed to the published version of the manuscript. Funding J.H.H. and N.N. are funded by Nella and Leon Benoziyo Center for Neurological Diseases; David and Fela Shapell Family Center for Genetic Disorders Research; Kekst Family Institute for Medical Genetics; Helen and Martin Kimmel Institute for Stem Cell Research; Flight Attendant Medical Research Council (FAMRI); Dr. Barry Sherman Center for Medicinal Chemistry; Pascal and Ilana Mantoux; Dr. Beth Rom-Rymer Stem Cell Research Fund; Edmond de Rothschild Foundations; Zantker Charitable Foundation; Estate of Zvia Zeroni; European Research Council (ERC-CoG); Israel Science Foundation (ISF); Minerva; Israel Cancer Research Fund (ICRF) and BSF.",
year = "2020",
month = mar,
day = "14",
doi = "10.3390/epigenomes4010005",
language = "الإنجليزيّة",
volume = "4",
journal = "Epigenomes",
issn = "2075-4655",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "1",
}