RNA inhibition highlights Cyclin D1 as a potential therapeutic target for mantle cell lymphoma

Shiri Weinstein; Rafi Emmanuel; Ashley M. Jacobi; Avigdor Abraham; Mark A. Behlke; Andrew G. Sprague; Tatiana I. Novobrantseva; Arnon Nagler; Dan Peer

doi:10.1371/journal.pone.0043343

RNA inhibition highlights Cyclin D1 as a potential therapeutic target for mantle cell lymphoma

Shiri Weinstein, Rafi Emmanuel, Ashley M. Jacobi, Avigdor Abraham, Mark A. Behlke, Andrew G. Sprague, Tatiana I. Novobrantseva, Arnon Nagler, Dan Peer

Department of Cell Research and Immunology

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

Abstract

Mantle cell lymphoma is characterized by a genetic translocation results in aberrant overexpression of the CCND1 gene, which encodes cyclin D1. This protein functions as a regulator of the cell cycle progression, hence is considered to play an important role in the pathogenesis of the disease. In this study, we used RNA interference strategies to examine whether cyclin D1 might serve as a therapeutic target for mantle cell lymphoma. Knocking down cyclin D1 resulted in significant growth retardation, cell cycle arrest, and most importantly, induction of apoptosis. These results mark cyclin D1 as a target for mantle cell lymphoma and emphasize the therapeutic potential hidden in its silencing.

Original language	English
Article number	e43343
Journal	PLoS ONE
Volume	7
Issue number	8
DOIs	https://doi.org/10.1371/journal.pone.0043343
State	Published - 14 Aug 2012

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title = "RNA inhibition highlights Cyclin D1 as a potential therapeutic target for mantle cell lymphoma",

abstract = "Mantle cell lymphoma is characterized by a genetic translocation results in aberrant overexpression of the CCND1 gene, which encodes cyclin D1. This protein functions as a regulator of the cell cycle progression, hence is considered to play an important role in the pathogenesis of the disease. In this study, we used RNA interference strategies to examine whether cyclin D1 might serve as a therapeutic target for mantle cell lymphoma. Knocking down cyclin D1 resulted in significant growth retardation, cell cycle arrest, and most importantly, induction of apoptosis. These results mark cyclin D1 as a target for mantle cell lymphoma and emphasize the therapeutic potential hidden in its silencing.",

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AU - Weinstein, Shiri

AU - Emmanuel, Rafi

AU - Jacobi, Ashley M.

AU - Abraham, Avigdor

AU - Behlke, Mark A.

AU - Sprague, Andrew G.

AU - Novobrantseva, Tatiana I.

AU - Nagler, Arnon

AU - Peer, Dan

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N2 - Mantle cell lymphoma is characterized by a genetic translocation results in aberrant overexpression of the CCND1 gene, which encodes cyclin D1. This protein functions as a regulator of the cell cycle progression, hence is considered to play an important role in the pathogenesis of the disease. In this study, we used RNA interference strategies to examine whether cyclin D1 might serve as a therapeutic target for mantle cell lymphoma. Knocking down cyclin D1 resulted in significant growth retardation, cell cycle arrest, and most importantly, induction of apoptosis. These results mark cyclin D1 as a target for mantle cell lymphoma and emphasize the therapeutic potential hidden in its silencing.

AB - Mantle cell lymphoma is characterized by a genetic translocation results in aberrant overexpression of the CCND1 gene, which encodes cyclin D1. This protein functions as a regulator of the cell cycle progression, hence is considered to play an important role in the pathogenesis of the disease. In this study, we used RNA interference strategies to examine whether cyclin D1 might serve as a therapeutic target for mantle cell lymphoma. Knocking down cyclin D1 resulted in significant growth retardation, cell cycle arrest, and most importantly, induction of apoptosis. These results mark cyclin D1 as a target for mantle cell lymphoma and emphasize the therapeutic potential hidden in its silencing.

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M3 - مقالة

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JO - PLoS ONE

JF - PLoS ONE

IS - 8

M1 - e43343

ER -

RNA inhibition highlights Cyclin D1 as a potential therapeutic target for mantle cell lymphoma

Abstract

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