Ribosomes are optimized for autocatalytic production

Shlomi Reuveni; Måns Ehrenberg; Johan Paulsson

doi:10.1038/nature22998

Ribosomes are optimized for autocatalytic production

Shlomi Reuveni, Måns Ehrenberg, Johan Paulsson

Research output: Contribution to journal › Article › peer-review

Abstract

Many fine-scale features of ribosomes have been explained in terms of function, revealing a molecular machine that is optimized for error-correction, speed and control. Here we demonstrate mathematically that many less well understood, larger-scale features of ribosomes - such as why a few ribosomal RNA molecules dominate the mass and why the ribosomal protein content is divided into 55-80 small, similarly sized segments - speed up their autocatalytic production.

Original language	English
Pages (from-to)	293-297
Number of pages	5
Journal	Nature
Volume	547
Issue number	7663
DOIs	https://doi.org/10.1038/nature22998
State	Published - 19 Jul 2017
Externally published	Yes

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10.1038/nature22998

Cite this

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title = "Ribosomes are optimized for autocatalytic production",

abstract = "Many fine-scale features of ribosomes have been explained in terms of function, revealing a molecular machine that is optimized for error-correction, speed and control. Here we demonstrate mathematically that many less well understood, larger-scale features of ribosomes - such as why a few ribosomal RNA molecules dominate the mass and why the ribosomal protein content is divided into 55-80 small, similarly sized segments - speed up their autocatalytic production.",

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AU - Paulsson, Johan

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AB - Many fine-scale features of ribosomes have been explained in terms of function, revealing a molecular machine that is optimized for error-correction, speed and control. Here we demonstrate mathematically that many less well understood, larger-scale features of ribosomes - such as why a few ribosomal RNA molecules dominate the mass and why the ribosomal protein content is divided into 55-80 small, similarly sized segments - speed up their autocatalytic production.

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DO - 10.1038/nature22998

M3 - مقالة

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Ribosomes are optimized for autocatalytic production

Abstract

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