Retinoic acid/calcite micro-carriers inserted in fibrin scaffolds modulate neuronal cell differentiation

Marianna Barbalinardo; Matteo Di Giosia; Iryna Polishchuk; Giulia Magnabosco; Simona Fermani; Fabio Biscarini; Matteo Calvaresi; Francesco Zerbetto; Graziella Pellegrini; Giuseppe Falini; Boaz Pokroy; Francesco Valle

doi:10.1039/c9tb01148j

Retinoic acid/calcite micro-carriers inserted in fibrin scaffolds modulate neuronal cell differentiation

Marianna Barbalinardo, Matteo Di Giosia, Iryna Polishchuk, Giulia Magnabosco, Simona Fermani, Fabio Biscarini, Matteo Calvaresi, Francesco Zerbetto, Graziella Pellegrini, Giuseppe Falini, Boaz Pokroy, Francesco Valle

Technion - Israel Institute of Technology

Research output: Contribution to journal › Article › peer-review

Abstract

The controlled release of cell differentiating agents is crucial in many aspects of regenerative medicine. Here we propose the use of hybrid calcite single crystals as micro-carriers for the controlled and localized release of retinoic acid, which is entrapped within the crystalline lattice. The release of retinoic acid occurs only in the proximity of stem cells, upon dissolution of the calcite hybrid crystals that are dispersed in the fibrin scaffold. These hybrid crystals provide a sustained dosage of the entrapped agent. The environment provided by this composite scaffold enables differentiation towards neuronal cells that form a three-dimensional neuronal network.

Original language	English
Pages (from-to)	5808-5813
Number of pages	6
Journal	Journal of Materials Chemistry B
Volume	7
Issue number	38
DOIs	https://doi.org/10.1039/c9tb01148j
State	Published - 14 Oct 2019

All Science Journal Classification (ASJC) codes

General Chemistry
Biomedical Engineering
General Materials Science

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10.1039/c9tb01148j

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Barbalinardo, M., Di Giosia, M., Polishchuk, I., Magnabosco, G., Fermani, S., Biscarini, F., Calvaresi, M., Zerbetto, F., Pellegrini, G., Falini, G., Pokroy, B., & Valle, F. (2019). Retinoic acid/calcite micro-carriers inserted in fibrin scaffolds modulate neuronal cell differentiation. Journal of Materials Chemistry B, 7(38), 5808-5813. https://doi.org/10.1039/c9tb01148j

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title = "Retinoic acid/calcite micro-carriers inserted in fibrin scaffolds modulate neuronal cell differentiation",

abstract = "The controlled release of cell differentiating agents is crucial in many aspects of regenerative medicine. Here we propose the use of hybrid calcite single crystals as micro-carriers for the controlled and localized release of retinoic acid, which is entrapped within the crystalline lattice. The release of retinoic acid occurs only in the proximity of stem cells, upon dissolution of the calcite hybrid crystals that are dispersed in the fibrin scaffold. These hybrid crystals provide a sustained dosage of the entrapped agent. The environment provided by this composite scaffold enables differentiation towards neuronal cells that form a three-dimensional neuronal network.",

author = "Marianna Barbalinardo and {Di Giosia}, Matteo and Iryna Polishchuk and Giulia Magnabosco and Simona Fermani and Fabio Biscarini and Matteo Calvaresi and Francesco Zerbetto and Graziella Pellegrini and Giuseppe Falini and Boaz Pokroy and Francesco Valle",

note = "Publisher Copyright: {\textcopyright} 2019 The Royal Society of Chemistry.",

year = "2019",

month = oct,

day = "14",

doi = "10.1039/c9tb01148j",

language = "الإنجليزيّة",

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Barbalinardo, M, Di Giosia, M, Polishchuk, I, Magnabosco, G, Fermani, S, Biscarini, F, Calvaresi, M, Zerbetto, F, Pellegrini, G, Falini, G, Pokroy, B & Valle, F 2019, 'Retinoic acid/calcite micro-carriers inserted in fibrin scaffolds modulate neuronal cell differentiation', Journal of Materials Chemistry B, vol. 7, no. 38, pp. 5808-5813. https://doi.org/10.1039/c9tb01148j

TY - JOUR

T1 - Retinoic acid/calcite micro-carriers inserted in fibrin scaffolds modulate neuronal cell differentiation

AU - Barbalinardo, Marianna

AU - Di Giosia, Matteo

AU - Polishchuk, Iryna

AU - Magnabosco, Giulia

AU - Fermani, Simona

AU - Biscarini, Fabio

AU - Calvaresi, Matteo

AU - Zerbetto, Francesco

AU - Pellegrini, Graziella

AU - Falini, Giuseppe

AU - Pokroy, Boaz

AU - Valle, Francesco

PY - 2019/10/14

Y1 - 2019/10/14

N2 - The controlled release of cell differentiating agents is crucial in many aspects of regenerative medicine. Here we propose the use of hybrid calcite single crystals as micro-carriers for the controlled and localized release of retinoic acid, which is entrapped within the crystalline lattice. The release of retinoic acid occurs only in the proximity of stem cells, upon dissolution of the calcite hybrid crystals that are dispersed in the fibrin scaffold. These hybrid crystals provide a sustained dosage of the entrapped agent. The environment provided by this composite scaffold enables differentiation towards neuronal cells that form a three-dimensional neuronal network.

AB - The controlled release of cell differentiating agents is crucial in many aspects of regenerative medicine. Here we propose the use of hybrid calcite single crystals as micro-carriers for the controlled and localized release of retinoic acid, which is entrapped within the crystalline lattice. The release of retinoic acid occurs only in the proximity of stem cells, upon dissolution of the calcite hybrid crystals that are dispersed in the fibrin scaffold. These hybrid crystals provide a sustained dosage of the entrapped agent. The environment provided by this composite scaffold enables differentiation towards neuronal cells that form a three-dimensional neuronal network.

UR - http://www.scopus.com/inward/record.url?scp=85072849199&partnerID=8YFLogxK

U2 - 10.1039/c9tb01148j

DO - 10.1039/c9tb01148j

M3 - مقالة

SN - 2050-750X

VL - 7

SP - 5808

EP - 5813

JO - Journal of Materials Chemistry B

JF - Journal of Materials Chemistry B

IS - 38

ER -

Retinoic acid/calcite micro-carriers inserted in fibrin scaffolds modulate neuronal cell differentiation

Abstract

All Science Journal Classification (ASJC) codes

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