Resistin-like Molecule α Provides Vitamin-A-Dependent Antimicrobial Protection in the Skin

Tamia A. Harris; Sureka Gattu; Daniel C. Propheter; Zheng Kuang; Shai Bel; Kelly A. Ruhn; Andrew L. Chara; Marshall Edwards; Chenlu Zhang; Jay Hyun Jo; Prithvi Raj; Christos C. Zouboulis; Heidi H. Kong; Julia A. Segre; Lora V. Hooper

doi:10.1016/j.chom.2019.04.004

Resistin-like Molecule α Provides Vitamin-A-Dependent Antimicrobial Protection in the Skin

Tamia A. Harris
, Sureka Gattu
, Daniel C. Propheter
, Zheng Kuang
, Shai Bel
, Kelly A. Ruhn
, Andrew L. Chara
, Marshall Edwards
, Chenlu Zhang
, Jay Hyun Jo
, Prithvi Raj
, Christos C. Zouboulis
, Heidi H. Kong
, Julia A. Segre
, Lora V. Hooper

Research output: Contribution to journal › Article › peer-review

Abstract

Vitamin A regulates skin immunity via unknown mechanisms. Harris et al. show that RELMα is an antimicrobial protein expressed by epidermal cells that shapes resident skin bacterial communities and limits skin infection. RELMα is induced by dietary vitamin A and mediates vitamin-A-dependent resistance to skin infection.

Original language	English
Pages (from-to)	777-788.e8
Journal	Cell Host and Microbe
Volume	25
Issue number	6
DOIs	https://doi.org/10.1016/j.chom.2019.04.004
State	Published - 12 Jun 2019
Externally published	Yes

Keywords

antimicrobial protein
bacteria
innate immunity
microbiome
skin
skin infection
vitamin A

ASJC Scopus subject areas

Parasitology
Microbiology
Virology

Access to Document

10.1016/j.chom.2019.04.004

Cite this

Harris, T. A., Gattu, S., Propheter, D. C., Kuang, Z., Bel, S., Ruhn, K. A., Chara, A. L., Edwards, M., Zhang, C., Jo, J. H., Raj, P., Zouboulis, C. C., Kong, H. H., Segre, J. A., & Hooper, L. V. (2019). Resistin-like Molecule α Provides Vitamin-A-Dependent Antimicrobial Protection in the Skin. Cell Host and Microbe, 25(6), 777-788.e8. https://doi.org/10.1016/j.chom.2019.04.004

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title = "Resistin-like Molecule α Provides Vitamin-A-Dependent Antimicrobial Protection in the Skin",

abstract = "Vitamin A regulates skin immunity via unknown mechanisms. Harris et al. show that RELMα is an antimicrobial protein expressed by epidermal cells that shapes resident skin bacterial communities and limits skin infection. RELMα is induced by dietary vitamin A and mediates vitamin-A-dependent resistance to skin infection.",

keywords = "antimicrobial protein, bacteria, innate immunity, microbiome, skin, skin infection, vitamin A",

author = "Harris, \{Tamia A.\} and Sureka Gattu and Propheter, \{Daniel C.\} and Zheng Kuang and Shai Bel and Ruhn, \{Kelly A.\} and Chara, \{Andrew L.\} and Marshall Edwards and Chenlu Zhang and Jo, \{Jay Hyun\} and Prithvi Raj and Zouboulis, \{Christos C.\} and Kong, \{Heidi H.\} and Segre, \{Julia A.\} and Hooper, \{Lora V.\}",

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year = "2019",

month = jun,

day = "12",

doi = "10.1016/j.chom.2019.04.004",

language = "English",

volume = "25",

pages = "777--788.e8",

journal = "Cell Host and Microbe",

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T1 - Resistin-like Molecule α Provides Vitamin-A-Dependent Antimicrobial Protection in the Skin

AU - Harris, Tamia A.

AU - Gattu, Sureka

AU - Propheter, Daniel C.

AU - Kuang, Zheng

AU - Bel, Shai

AU - Ruhn, Kelly A.

AU - Chara, Andrew L.

AU - Edwards, Marshall

AU - Zhang, Chenlu

AU - Jo, Jay Hyun

AU - Raj, Prithvi

AU - Zouboulis, Christos C.

AU - Kong, Heidi H.

AU - Segre, Julia A.

AU - Hooper, Lora V.

PY - 2019/6/12

Y1 - 2019/6/12

N2 - Vitamin A regulates skin immunity via unknown mechanisms. Harris et al. show that RELMα is an antimicrobial protein expressed by epidermal cells that shapes resident skin bacterial communities and limits skin infection. RELMα is induced by dietary vitamin A and mediates vitamin-A-dependent resistance to skin infection.

AB - Vitamin A regulates skin immunity via unknown mechanisms. Harris et al. show that RELMα is an antimicrobial protein expressed by epidermal cells that shapes resident skin bacterial communities and limits skin infection. RELMα is induced by dietary vitamin A and mediates vitamin-A-dependent resistance to skin infection.

KW - antimicrobial protein

KW - bacteria

KW - innate immunity

KW - microbiome

KW - skin

KW - skin infection

KW - vitamin A

UR - https://www.scopus.com/pages/publications/85066780871

U2 - 10.1016/j.chom.2019.04.004

DO - 10.1016/j.chom.2019.04.004

M3 - Article

C2 - 31101494

SN - 1931-3128

VL - 25

SP - 777-788.e8

JO - Cell Host and Microbe

JF - Cell Host and Microbe

IS - 6

ER -

Resistin-like Molecule α Provides Vitamin-A-Dependent Antimicrobial Protection in the Skin

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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