Abstract
Resident cardiac stem/progenitor cells are implicated in cell replacement, repair and maintenance of the myocardium. These cells are already committed to a specific cardiomyogenic pathway. Stimulation of these cells in injured hearts can open new options in cardiovascular regenerative medicine, and advance our approach to patients with end-stage heart failure. This chapter reviews some of the recent discoveries in the field of resident cardiac stem/progenitor cells, focusing first on human cardiac stem cell characteristics and reparative potential, including the concept of myocardial regeneration. In addition, we will briefly review recent clinical trials, controversies and unresolved issues.
| Original language | English |
|---|---|
| Title of host publication | Adult and Pluripotent Stem Cells |
| Subtitle of host publication | Potential for Regenerative Medicine of the Cardiovascular System |
| Publisher | Springer Netherlands |
| Pages | 21-35 |
| Number of pages | 15 |
| ISBN (Electronic) | 9789401786577 |
| ISBN (Print) | 9401786569, 9789401786560 |
| DOIs | |
| State | Published - 1 Dec 2013 |
Keywords
- Cardiac progenitor cells
- Clinical stem cell trials
- Intermyocardial injection
- Repair of myocardium
- Resident cardiac stem cells
- Self-renewal of cardiomyocytes
- Stem cell transplantation
All Science Journal Classification (ASJC) codes
- General Medicine