TY - JOUR
T1 - Residence near industrial complex and cancer incidence
T2 - A registry-based cohort of 1,022,637 participants with a follow-up of 21 years, Israel
AU - Kayyal-Tarabeia, Inass
AU - Blank, Michael
AU - Zick, Aviad
AU - Agay-Shay, Keren
N1 - Publisher Copyright: © 2022 Elsevier Inc.
PY - 2023/1/1
Y1 - 2023/1/1
N2 - Background: Industrial complex (IC) residence is associated with higher cancer incidence in adults and children. However, the effect on young adults and the residence duration are not well described. Since the beginning of the 20th century, the Haifa bay area (HBA) has a major IC area with petrochemical industry complex and many other industries. The objectives of the current study were to estimate the association between IC residence and cancer incidence and to evaluate the effect of the residence duration. Methods: This study is a registry-based cohort (N = 1,022,637) with a follow-up of 21 years. Cox regression models were used to evaluate the associations (hazards ratios (HR) and its 95% confidence intervals (CIs)) between HBA residence and incidence of all cancer sites (n = 62,049) and for site-specific cancer types including: lung cancer (n = 5398), bladder cancer (n = 3790), breast cancer (n = 11,310), prostate cancer (n = 6389) skin cancer (n = 4651), pancreatic cancer (n = 2144) and colorectal cancer (n = 8675). We evaluated the effect of the duration of exposure as categories of 7 years for those with 15 years of follow-up. Results: IC residence was associated with higher risk for all cancer sites (HR:1.09, 95% CI: 1.06–1.12), for site-specific cancer incidence including: lung cancer (HR:1.14, 95% CI: 1.04–1.23), bladder cancer (HR:1.11, 95% CI: 1.01–1.23), breast cancer (HR:1.04, 95% CI: 0.98–1.10), prostate cancer (HR:1.07, 95% CI: 0.99–1.16), skin cancer (HR:1.22, 95% CI: 1.12–1.33) and colorectal cancer (HR:1.10, 95%CI: 1.03–1.17). Similar risk was also observed among young adults (HR: 1.10, 95% CI: 1.00–1.20). In the analyses for the duration of exposure, IC residence was associated with higher risk for all cancer site for the longest residence duration (15–21 years: HR: 1.08, 95% CI: 1.04–1.13). Conclusions: Harmful associations were found between IC residence and incidence of all cancer sites and site-specific cancers types. Our findings add to the limited evidence of associations between IC residence and cancer in young adults.
AB - Background: Industrial complex (IC) residence is associated with higher cancer incidence in adults and children. However, the effect on young adults and the residence duration are not well described. Since the beginning of the 20th century, the Haifa bay area (HBA) has a major IC area with petrochemical industry complex and many other industries. The objectives of the current study were to estimate the association between IC residence and cancer incidence and to evaluate the effect of the residence duration. Methods: This study is a registry-based cohort (N = 1,022,637) with a follow-up of 21 years. Cox regression models were used to evaluate the associations (hazards ratios (HR) and its 95% confidence intervals (CIs)) between HBA residence and incidence of all cancer sites (n = 62,049) and for site-specific cancer types including: lung cancer (n = 5398), bladder cancer (n = 3790), breast cancer (n = 11,310), prostate cancer (n = 6389) skin cancer (n = 4651), pancreatic cancer (n = 2144) and colorectal cancer (n = 8675). We evaluated the effect of the duration of exposure as categories of 7 years for those with 15 years of follow-up. Results: IC residence was associated with higher risk for all cancer sites (HR:1.09, 95% CI: 1.06–1.12), for site-specific cancer incidence including: lung cancer (HR:1.14, 95% CI: 1.04–1.23), bladder cancer (HR:1.11, 95% CI: 1.01–1.23), breast cancer (HR:1.04, 95% CI: 0.98–1.10), prostate cancer (HR:1.07, 95% CI: 0.99–1.16), skin cancer (HR:1.22, 95% CI: 1.12–1.33) and colorectal cancer (HR:1.10, 95%CI: 1.03–1.17). Similar risk was also observed among young adults (HR: 1.10, 95% CI: 1.00–1.20). In the analyses for the duration of exposure, IC residence was associated with higher risk for all cancer site for the longest residence duration (15–21 years: HR: 1.08, 95% CI: 1.04–1.13). Conclusions: Harmful associations were found between IC residence and incidence of all cancer sites and site-specific cancers types. Our findings add to the limited evidence of associations between IC residence and cancer in young adults.
KW - Cancer incidence
KW - Industrial complex
KW - Site-specific
KW - Young adults
UR - http://www.scopus.com/inward/record.url?scp=85139368731&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.envres.2022.114471
DO - https://doi.org/10.1016/j.envres.2022.114471
M3 - Article
C2 - 36208787
SN - 0013-9351
VL - 216
JO - Environmental Research
JF - Environmental Research
M1 - 114471
ER -