TY - JOUR
T1 - Representation of three-dimensional space in the hippocampus of flying bats
AU - Yartsev, Michael M.
AU - Ulanovsky, Nachum
N1 - European Research Council (ERC-NEUROBAT); Human Frontiers Science Program [HFSP RGP0062/2009-C]; Israel Science Foundation [ISF 1017/08]; Minerva Foundation; Lev-Zion predoctoral excellence fellowshipWe thank A. Treves, D. Derdikman, J.-M. Fellous, L. Las, Y. Yovel, M. Ahrens, and C. Brody for comments on the manuscript; R. Raz, K. Kamenitz, and M. Geva-Sagiv for the 3D trajectory reconstruction system; C. Stengel for the neural telemetry system; B. Pasmantirer and G. Ankaoua for mechanical designs; A. Rubin and A. Averkin for assistance with neural recordings and video calibrations; S. Kaufman, T. Dayan, and S. Dror for bat training; M. Weinberg and A. Tuval for veterinary oversight; C. Ra'anan and R. Eilam for histology; and M. P. Witter for advice on reconstruction of tetrode-track locations. This study was supported by research grants from the European Research Council (ERC-NEUROBAT), the Human Frontiers Science Program (HFSP RGP0062/2009-C), the Israel Science Foundation (ISF 1017/08), and the Minerva Foundation to N.U. and a Lev-Zion predoctoral excellence fellowship to M.M.Y.
PY - 2013/4/19
Y1 - 2013/4/19
N2 - Many animals, on air, water, or land, navigate in three-dimensional (3D) environments, yet it remains unclear how brain circuits encode the animal's 3D position. We recorded single neurons in freely flying bats, using a wireless neural-telemetry system, and studied how hippocampal place cells encode 3D volumetric space during flight. Individual place cells were active in confined 3D volumes, and in >90% of the neurons, all three axes were encoded with similar resolution. The 3D place fields from different neurons spanned different locations and collectively represented uniformly the available space in the room. Theta rhythmicity was absent in the firing patterns of 3D place cells. These results suggest that the bat hippocampus represents 3D volumetric space by a uniform and nearly isotropic rate code.
AB - Many animals, on air, water, or land, navigate in three-dimensional (3D) environments, yet it remains unclear how brain circuits encode the animal's 3D position. We recorded single neurons in freely flying bats, using a wireless neural-telemetry system, and studied how hippocampal place cells encode 3D volumetric space during flight. Individual place cells were active in confined 3D volumes, and in >90% of the neurons, all three axes were encoded with similar resolution. The 3D place fields from different neurons spanned different locations and collectively represented uniformly the available space in the room. Theta rhythmicity was absent in the firing patterns of 3D place cells. These results suggest that the bat hippocampus represents 3D volumetric space by a uniform and nearly isotropic rate code.
UR - http://www.scopus.com/inward/record.url?scp=84876304111&partnerID=8YFLogxK
U2 - https://doi.org/10.1126/science.1235338
DO - https://doi.org/10.1126/science.1235338
M3 - مقالة
SN - 0036-8075
VL - 340
SP - 367
EP - 372
JO - Science
JF - Science
IS - 6130
ER -