Relevance of aneuploidy for cancer therapies targeting the spindle assembly checkpoint and KIF18A

Yael Cohen-Sharir; Uri Ben-David

doi:https://doi.org/10.1080/23723556.2021.1915075

Relevance of aneuploidy for cancer therapies targeting the spindle assembly checkpoint and KIF18A

Yael Cohen-Sharir, Uri Ben-David

Human Molecular Genetics Biochemistry

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

Abstract

Aneuploidy, a common feature of cancer cells, results in increased sensitivity to the inhibition of the spindle assembly checkpoint (SAC) and the mitotic motor protein Kinesin Family Member 18A (KIF18A). We discuss the importance of drugs targeting SAC core members and KIF18A. We stress the need to assess the sensitivity to this class of drugs at appropriate time points, and propose that aneuploidy could serve as a biomarker to stratify patients for SAC-targeting treatments.

Original language	English
Article number	1915075
Journal	Molecular and Cellular Oncology
Volume	8
Issue number	3
DOIs	https://doi.org/10.1080/23723556.2021.1915075
State	Published - 2021

Keywords

Aneuploidy
KIF18A
SAC
cancer
cancer therapies
spindle assembly checkpoint

All Science Journal Classification (ASJC) codes

Molecular Medicine
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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https://doi.org/10.1080/23723556.2021.1915075

Cite this

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title = "Relevance of aneuploidy for cancer therapies targeting the spindle assembly checkpoint and KIF18A",

abstract = "Aneuploidy, a common feature of cancer cells, results in increased sensitivity to the inhibition of the spindle assembly checkpoint (SAC) and the mitotic motor protein Kinesin Family Member 18A (KIF18A). We discuss the importance of drugs targeting SAC core members and KIF18A. We stress the need to assess the sensitivity to this class of drugs at appropriate time points, and propose that aneuploidy could serve as a biomarker to stratify patients for SAC-targeting treatments.",

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AU - Ben-David, Uri

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AB - Aneuploidy, a common feature of cancer cells, results in increased sensitivity to the inhibition of the spindle assembly checkpoint (SAC) and the mitotic motor protein Kinesin Family Member 18A (KIF18A). We discuss the importance of drugs targeting SAC core members and KIF18A. We stress the need to assess the sensitivity to this class of drugs at appropriate time points, and propose that aneuploidy could serve as a biomarker to stratify patients for SAC-targeting treatments.

KW - Aneuploidy

KW - KIF18A

KW - SAC

KW - cancer

KW - cancer therapies

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ER -

Relevance of aneuploidy for cancer therapies targeting the spindle assembly checkpoint and KIF18A

Abstract

Keywords

All Science Journal Classification (ASJC) codes

UN SDGs

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