Regulation of the Ras-MAPK and PI3K-mTOR signalling pathways by alternative splicing in cancer

Zahava Siegfried, Serena Bonomi, Claudia Ghigna, Rotem Karni

Research output: Contribution to journalReview articlepeer-review

Abstract

Alternative splicing is a fundamental step in regulation of gene expression of many tumor suppressors and oncogenes in cancer. Signalling through the Ras-MAPK and PI3K-mTOR pathways is misregulated and hyperactivated in most types of cancer. However, the regulation of the Ras-MAPK and PI3K-mTOR signalling pathways by alternative splicing is less well established. Recent studies have shown the contribution of alternative splicing regulation of these signalling pathways which can lead to cellular transformation, cancer development, and tumor maintenance. This review will discuss findings in the literature which describe new modes of regulation of components of the Ras-MAPK and PI3K-mTOR signalling pathways by alternative splicing. We will also describe the mechanisms by which signals from extracellular stimuli can be communicated to the splicing machinery and to specific RNA-binding proteins that ultimately control exon definition events.

Original languageAmerican English
Article number568931
JournalInternational Journal of Cell Biology
DOIs
StatePublished - 2013

All Science Journal Classification (ASJC) codes

  • Cell Biology

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