Regulation of Hepatic Metabolism, Recent Advances, and Future Perspectives

Kfir Sharabi, Clint D.J. Tavares, Pere Puigserver

Research output: Contribution to journalReview articlepeer-review


Purpose of Review: The purpose of this review is to provide a brief summary of recent advances in our understanding of liver metabolism. The critical role of the liver in controlling whole-body energy homeostasis makes such understanding crucial to efficiently design new treatments for metabolic syndrome diseases, including type 2 diabetes (T2D). Recent Findings: Significant advances have been made regarding our understanding of the direct and indirect effects of insulin on hepatic metabolism and the communication between the liver and other tissues. Moreover, the catabolic functions of glucagon, as well as the importance of hepatic redox status for the regulation of glucose production, are emerging as potential targets to reduce hyperglycemia. Summary: A resolution to the long-standing question “insulin suppression of hepatic glucose production, direct or indirect effect?” is starting to emerge. New advances in our understanding of important fasting-induced hepatic metabolic fluxes may help design better therapies for T2D.

Original languageAmerican English
Article number98
JournalCurrent Diabetes Reports
Issue number10
StatePublished - 1 Oct 2019
Externally publishedYes


  • Diabetes
  • Glucagon
  • Glucose homeostasis
  • Insulin
  • Liver
  • Metabolism

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism


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