Abstract
In addition to their conventional role as a versatile transport system, blood vessels provide signals controlling organ development, regeneration, and stem cell behavior. In the skeletal system, certain capillaries support perivascular osteoprogenitor cells and thereby control bone formation. Blood vessels are also a critical component of niche microenvironments for hematopoietic stem cells. Here we discuss key pathways and factors controlling endothelial cell behavior in bone, the role of vessels in osteogenesis, and the nature of vascular stem cell niches in bone marrow.
Original language | English |
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Pages (from-to) | 649-675 |
Number of pages | 30 |
Journal | Annual Review of Cell and Developmental Biology |
Volume | 32 |
Early online date | 17 Aug 2016 |
DOIs | |
State | Published - 6 Oct 2016 |
Keywords
- Angiocrine factors
- Bone angiogenesis
- Hematopoietic stem cells
- Vascular niche
All Science Journal Classification (ASJC) codes
- Cell Biology
- Developmental Biology