Regulation of Hematopoiesis and Osteogenesis by Blood Vessel-Derived Signals

SK Ramasamy, AP Kusumbe, Tomer Itkin, Shiri Gur-Cohen, Tsvee Lapidot, RH Adams

Research output: Contribution to journalReview articlepeer-review

Abstract

In addition to their conventional role as a versatile transport system, blood vessels provide signals controlling organ development, regeneration, and stem cell behavior. In the skeletal system, certain capillaries support perivascular osteoprogenitor cells and thereby control bone formation. Blood vessels are also a critical component of niche microenvironments for hematopoietic stem cells. Here we discuss key pathways and factors controlling endothelial cell behavior in bone, the role of vessels in osteogenesis, and the nature of vascular stem cell niches in bone marrow.
Original languageEnglish
Pages (from-to)649-675
Number of pages30
JournalAnnual Review of Cell and Developmental Biology
Volume32
Early online date17 Aug 2016
DOIs
StatePublished - 6 Oct 2016

Keywords

  • Angiocrine factors
  • Bone angiogenesis
  • Hematopoietic stem cells
  • Vascular niche

All Science Journal Classification (ASJC) codes

  • Cell Biology
  • Developmental Biology

Fingerprint

Dive into the research topics of 'Regulation of Hematopoiesis and Osteogenesis by Blood Vessel-Derived Signals'. Together they form a unique fingerprint.

Cite this