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Regio- and Stereoselective Synthesis of Fully Substituted Silyl Enol Ethers of Ketones and Aldehydes in Acyclic Systems

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Abstract

The regio- and stereoselective preparation of fully substituted and stereodefined silyl enol ethers of ketones and aldehydes through an allyl-Brook rearrangement is reported. This fast and efficient method proceeds from a mixture of E and Z isomers of easily accessible starting materials.

Original languageEnglish
Pages (from-to)14995-14999
Number of pages5
JournalAngewandte Chemie - International Edition
Volume58
Issue number42
DOIs
StatePublished - 14 Oct 2019

Keywords

  • Brook rearrangement
  • carbonyl compounds
  • hydroxy silanes
  • silyl enol ethers
  • stereochemistry

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry

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