@article{7b8c7273b1694798b7e71c268d4fcf06,
title = "Recurrent inactivating RASA2 mutations in melanoma",
abstract = "Analysis of 501 melanoma exomes identified RASA2, encoding a RasGAP, as a tumor-suppressor gene mutated in 5% of melanomas. Recurrent loss-of-function mutations in RASA2 were found to increase RAS activation, melanoma cell growth and migration. RASA2 expression was lost in >= 30% of human melanomas and was associated with reduced patient survival. These findings identify RASA2 inactivation as a melanoma driver and highlight the importance of RasGAPs in cancer.",
author = "Rand Arafeh and Nouar Qutob and Rafi Emmanuel and Alona Keren-Paz and Jason Madore and Abdel Elkahloun and Wilmott, {James S.} and Gartner, {Jared J.} and {Di Pizio}, Antonella and Sabina Winograd-Katz and Sivasish Sindiri and Ron Rotkopf and Ken Dutton-Regester and Peter Johansson and Pritchard, {Antonia L.} and Nicola Waddell and Hill, {Victoria K.} and Lin, {Jimmy C.} and Yael Hevroni and Rosenberg, {Steven A.} and Javed Khan and Shifra Ben-Dor and Niv, {Masha Y.} and Igor Ulitsky and Mann, {Graham J.} and Scolyer, {Richard A.} and Hayward, {Nicholas K.} and Yardena Samuels",
note = "Publisher Copyright: {\textcopyright} 2015 Nature America, Inc. All rights reserved.",
year = "2015",
month = dec,
day = "1",
doi = "https://doi.org/10.1038/ng.3427",
language = "الإنجليزيّة",
volume = "47",
pages = "1408--1410",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "12",
}