Reciprocal changes in phosphorylation and methylation of mammalian brain sodium channels in response to seizures

Je Hyun Baek; Moran Rubinstein; Todd Scheuer; James S. Trimmer

doi:10.1074/jbc.M114.562785

Reciprocal changes in phosphorylation and methylation of mammalian brain sodium channels in response to seizures

Je Hyun Baek, Moran Rubinstein, Todd Scheuer, James S. Trimmer

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Sodium channels underlie neuronal excitability and are regulated by seizures. Results: Mass spectrometric analysis of brain sodium channels revealed novel phosphorylation and methylation sites that decreased and increased, respectively, after seizures. Inducing methylation increased sodium channel activity. Conclusion: Reciprocal phosphorylation and methylation after seizures will alter sodium channel function. Significance: Such regulation would impact neuronal excitability.

Original language	English
Pages (from-to)	15363-15373
Number of pages	11
Journal	Journal of Biological Chemistry
Volume	289
Issue number	22
DOIs	https://doi.org/10.1074/jbc.M114.562785
State	Published - 30 May 2014
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M114.562785

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title = "Reciprocal changes in phosphorylation and methylation of mammalian brain sodium channels in response to seizures",

abstract = "Background: Sodium channels underlie neuronal excitability and are regulated by seizures. Results: Mass spectrometric analysis of brain sodium channels revealed novel phosphorylation and methylation sites that decreased and increased, respectively, after seizures. Inducing methylation increased sodium channel activity. Conclusion: Reciprocal phosphorylation and methylation after seizures will alter sodium channel function. Significance: Such regulation would impact neuronal excitability.",

author = "Baek, {Je Hyun} and Moran Rubinstein and Todd Scheuer and Trimmer, {James S.}",

year = "2014",

month = may,

day = "30",

doi = "10.1074/jbc.M114.562785",

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T1 - Reciprocal changes in phosphorylation and methylation of mammalian brain sodium channels in response to seizures

AU - Baek, Je Hyun

AU - Rubinstein, Moran

AU - Scheuer, Todd

AU - Trimmer, James S.

PY - 2014/5/30

Y1 - 2014/5/30

N2 - Background: Sodium channels underlie neuronal excitability and are regulated by seizures. Results: Mass spectrometric analysis of brain sodium channels revealed novel phosphorylation and methylation sites that decreased and increased, respectively, after seizures. Inducing methylation increased sodium channel activity. Conclusion: Reciprocal phosphorylation and methylation after seizures will alter sodium channel function. Significance: Such regulation would impact neuronal excitability.

AB - Background: Sodium channels underlie neuronal excitability and are regulated by seizures. Results: Mass spectrometric analysis of brain sodium channels revealed novel phosphorylation and methylation sites that decreased and increased, respectively, after seizures. Inducing methylation increased sodium channel activity. Conclusion: Reciprocal phosphorylation and methylation after seizures will alter sodium channel function. Significance: Such regulation would impact neuronal excitability.

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U2 - 10.1074/jbc.M114.562785

DO - 10.1074/jbc.M114.562785

M3 - مقالة

SN - 0021-9258

VL - 289

SP - 15363

EP - 15373

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 22

ER -

Reciprocal changes in phosphorylation and methylation of mammalian brain sodium channels in response to seizures

Abstract

All Science Journal Classification (ASJC) codes

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