Receptor tyrosine kinases: Structure, functions and role in human disease

Deric L. Wheeler; Yosef Yarden

doi:10.1007/978-1-4939-2053-2

Receptor tyrosine kinases: Structure, functions and role in human disease

Deric L. Wheeler, Yosef Yarden

Department of Immunology and Regenerative Biology

Weizmann Institute of Science

Research output: Book/Report › Book › peer-review

Abstract

Receptor tyrosine kinases (RTKs) play critical roles in embryogenesis, normal physiology and several diseases, and over the last decade they became the "Number 1" targets of cancer drugs. "Receptor Tyrosine Kinase: Structure, Functions and Role in Human Disease" systematically covers, for the first time, the shared structural and functional features of the RTK family. Understanding the evolutionary origin of the 58 RTKs, their roles in invertebrates and in human, as well as downstream signaling pathways, is essential for fundamental research and for attempts to develop pharmacological agents able to enhance or intercept their actions. The assembly of chapters written by experts underscores commonalities and is an ideal companion volume to "The Receptor Tyrosine Kinase Family," which refers to specific subfamilies of RTKs, along with their unique landmarks.

Original language	English
Publisher	Springer New York
Number of pages	440
ISBN (Electronic)	9781493920532
ISBN (Print)	9781493920525
DOIs	https://doi.org/10.1007/978-1-4939-2053-2
State	Published - 1 Jan 2015

All Science Journal Classification (ASJC) codes

General Biochemistry,Genetics and Molecular Biology
General Medicine

Access to Document

10.1007/978-1-4939-2053-2

Cite this

@book{8baa43e745cd40909ac8a87383e26108,

title = "Receptor tyrosine kinases: Structure, functions and role in human disease",

abstract = "Receptor tyrosine kinases (RTKs) play critical roles in embryogenesis, normal physiology and several diseases, and over the last decade they became the {"}Number 1{"} targets of cancer drugs. {"}Receptor Tyrosine Kinase: Structure, Functions and Role in Human Disease{"} systematically covers, for the first time, the shared structural and functional features of the RTK family. Understanding the evolutionary origin of the 58 RTKs, their roles in invertebrates and in human, as well as downstream signaling pathways, is essential for fundamental research and for attempts to develop pharmacological agents able to enhance or intercept their actions. The assembly of chapters written by experts underscores commonalities and is an ideal companion volume to {"}The Receptor Tyrosine Kinase Family,{"} which refers to specific subfamilies of RTKs, along with their unique landmarks.",

author = "Wheeler, {Deric L.} and Yosef Yarden",

note = "Publisher Copyright: {\textcopyright} Springer Science+Business Media New York 2015.",

year = "2015",

month = jan,

day = "1",

doi = "10.1007/978-1-4939-2053-2",

language = "الإنجليزيّة",

isbn = "9781493920525",

publisher = "Springer New York",

address = "الولايات المتّحدة",

}

TY - BOOK

T1 - Receptor tyrosine kinases

T2 - Structure, functions and role in human disease

AU - Wheeler, Deric L.

AU - Yarden, Yosef

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Receptor tyrosine kinases (RTKs) play critical roles in embryogenesis, normal physiology and several diseases, and over the last decade they became the "Number 1" targets of cancer drugs. "Receptor Tyrosine Kinase: Structure, Functions and Role in Human Disease" systematically covers, for the first time, the shared structural and functional features of the RTK family. Understanding the evolutionary origin of the 58 RTKs, their roles in invertebrates and in human, as well as downstream signaling pathways, is essential for fundamental research and for attempts to develop pharmacological agents able to enhance or intercept their actions. The assembly of chapters written by experts underscores commonalities and is an ideal companion volume to "The Receptor Tyrosine Kinase Family," which refers to specific subfamilies of RTKs, along with their unique landmarks.

AB - Receptor tyrosine kinases (RTKs) play critical roles in embryogenesis, normal physiology and several diseases, and over the last decade they became the "Number 1" targets of cancer drugs. "Receptor Tyrosine Kinase: Structure, Functions and Role in Human Disease" systematically covers, for the first time, the shared structural and functional features of the RTK family. Understanding the evolutionary origin of the 58 RTKs, their roles in invertebrates and in human, as well as downstream signaling pathways, is essential for fundamental research and for attempts to develop pharmacological agents able to enhance or intercept their actions. The assembly of chapters written by experts underscores commonalities and is an ideal companion volume to "The Receptor Tyrosine Kinase Family," which refers to specific subfamilies of RTKs, along with their unique landmarks.

UR - http://www.scopus.com/inward/record.url?scp=84944590980&partnerID=8YFLogxK

U2 - 10.1007/978-1-4939-2053-2

DO - 10.1007/978-1-4939-2053-2

M3 - كتاب

SN - 9781493920525

BT - Receptor tyrosine kinases

PB - Springer New York

ER -

Receptor tyrosine kinases: Structure, functions and role in human disease

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this