Ready, set, cleave: Proteases in action

Seth J. Salpeter; Galia Blum

doi:10.1016/j.chembiol.2013.02.004

Ready, set, cleave: Proteases in action

Seth J. Salpeter, Galia Blum

School of Pharmacy

The Hebrew University of Jerusalem

Research output: Contribution to journal › Short survey › peer-review

Abstract

Activity-based probes are small molecules that can be used to monitor enzyme activity by covalently binding to specific residues in the active site. In this issue of Chemistry & Biology, Lu and colleagues developed a specific fluorescent activity-based probe that targets the papain-like cysteine bacterial type III effector protease AvrPphB and used it to demonstrate the regulation of the protease secretion and pathogenesis.

Original language	English
Pages (from-to)	137-138
Number of pages	2
Journal	Chemistry and Biology
Volume	20
Issue number	2
DOIs	https://doi.org/10.1016/j.chembiol.2013.02.004
State	Published - 21 Feb 2013

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmacology
Drug Discovery
Clinical Biochemistry

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10.1016/j.chembiol.2013.02.004

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title = "Ready, set, cleave: Proteases in action",

abstract = "Activity-based probes are small molecules that can be used to monitor enzyme activity by covalently binding to specific residues in the active site. In this issue of Chemistry \& Biology, Lu and colleagues developed a specific fluorescent activity-based probe that targets the papain-like cysteine bacterial type III effector protease AvrPphB and used it to demonstrate the regulation of the protease secretion and pathogenesis.",

author = "Salpeter, \{Seth J.\} and Galia Blum",

year = "2013",

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doi = "10.1016/j.chembiol.2013.02.004",

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TY - JOUR

T1 - Ready, set, cleave

T2 - Proteases in action

AU - Salpeter, Seth J.

AU - Blum, Galia

PY - 2013/2/21

Y1 - 2013/2/21

N2 - Activity-based probes are small molecules that can be used to monitor enzyme activity by covalently binding to specific residues in the active site. In this issue of Chemistry & Biology, Lu and colleagues developed a specific fluorescent activity-based probe that targets the papain-like cysteine bacterial type III effector protease AvrPphB and used it to demonstrate the regulation of the protease secretion and pathogenesis.

AB - Activity-based probes are small molecules that can be used to monitor enzyme activity by covalently binding to specific residues in the active site. In this issue of Chemistry & Biology, Lu and colleagues developed a specific fluorescent activity-based probe that targets the papain-like cysteine bacterial type III effector protease AvrPphB and used it to demonstrate the regulation of the protease secretion and pathogenesis.

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U2 - 10.1016/j.chembiol.2013.02.004

DO - 10.1016/j.chembiol.2013.02.004

M3 - عرض مختصر

SN - 1074-5521

VL - 20

SP - 137

EP - 138

JO - Chemistry and Biology

JF - Chemistry and Biology

IS - 2

ER -

Ready, set, cleave: Proteases in action

Abstract

All Science Journal Classification (ASJC) codes

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