TY - GEN
T1 - Rapid antifungal susceptibility testing on silicon microwells
AU - Heuer, Christopher
AU - Leonard, Heidi
AU - Nitzan, Nadav
AU - Lavy-Alperovitch, Ariella
AU - Massad-Ivanir, Naama
AU - Bahnemann, Janina
AU - Scheper, Thomas
AU - Segal, Ester
N1 - Publisher Copyright: © 2020 CBMS-0001
PY - 2020
Y1 - 2020
N2 - In this work, we present a sensing system for rapid antifungal susceptibility testing (AFST). The sensor is based on silicon-based diffraction gratings; their microstructure allows to capture the fungal conidia and monitor their subsequent growth on a solid-liquid interface. As a proof of concept, we use Aspergillus Niger (A. Niger) and study its growth and response to common antifungals (at varying concentrations) by monitoring changes in the intensity of reflected light from the grating. The assay is employed for the determination of minimum inhibitory concentration (MIC) values and allows expeditious AFST within 12 h, compared to ~1-2 days using gold standard methods.
AB - In this work, we present a sensing system for rapid antifungal susceptibility testing (AFST). The sensor is based on silicon-based diffraction gratings; their microstructure allows to capture the fungal conidia and monitor their subsequent growth on a solid-liquid interface. As a proof of concept, we use Aspergillus Niger (A. Niger) and study its growth and response to common antifungals (at varying concentrations) by monitoring changes in the intensity of reflected light from the grating. The assay is employed for the determination of minimum inhibitory concentration (MIC) values and allows expeditious AFST within 12 h, compared to ~1-2 days using gold standard methods.
KW - Antifungal Susceptibility Testing
KW - Sensors
KW - Silicon Microwell Diffraction Gratings
UR - http://www.scopus.com/inward/record.url?scp=85098262497&partnerID=8YFLogxK
M3 - منشور من مؤتمر
T3 - MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences
SP - 601
EP - 602
BT - MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences
T2 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020
Y2 - 4 October 2020 through 9 October 2020
ER -