@article{b4e8d0cc0cff4968983abed75e058fc6,
title = "Rac1 functions downstream of miR-142 in regulation of erythropoiesis",
abstract = "Hematopoietic-specific miR-142 is a critical regulator of various blood cell lineages including CD4+ dendritic cells1 and platelet biogenesis in megakaryocytes.2 Furthermore, we recently reported that miR-142 is required in order to maintain the biconcave shape of erythrocytes, their structural resilience and lifespan, through a mechanism that involves actin filament homeostasis.3 Here, we used a mouse loss of function allele to characterize a new axis, where miR-142 functions upstream of Rac1 in regulating erythropoiesis.",
author = "Natalia Rivkin and Elik Chapnik and Yehudit Birger and Eran Yanowski and Caterina Curato and Alexander Mildner and Ziv Porat and Gail Amir and Shai Izraeli and Steffen Jung and Eran Hornstein",
note = "The authors would like to thank Ofira Higfa and Yehudah Melamed for veterinary services and husbandry, and Dr. Joseph Lotem for helpful discussions, Diana Rashkovan Varol and Tegest Aychek for technical assistance, Gil Hornung for bioinformatics. Funding: the work is funded by the Minerva Foundation and Minna-James-Heineman Stiftung through Minerva. Work at the Hornstein Lab is further funded by an ERC consolidator program (617351), Israel Science Foundation, the Legacy-Heritage program, Bruno and Ilse Frick Foundation for Research on ALS, the ALS Therapy Alliance, the Motor Neurone Disease Association (UK), the Thierry Latran Foundation for ALS research, the ERA-Net for Research Programmes on Rare Diseases (FP7), A. Alfred Taubman through IsrALS; Teva Pharmaceutical Industries Ltd. as part of the Israeli National Network of Excellence in Neuroscience (NNE); Yeda-Sela, Yeda-CEO, Israel Ministry of Trade and Industry, Y. Leon Benoziyo Institute for Molecular Medicine, the Kekst Family Institute for Medical Genetics, the David and Fela Shapell Family Center for Genetic Disorders Research, the Crown Human Genome Center, the Nathan, Shirley, Philip and Charlene Vener New Scientist Fund, Julius and Ray Charlestein Foundation, the Fraida Foundation, the Wolfson Family Charitable Trust, the Adelis Foundation, MERCK (UK), Maria Halphen, and the Estates of Fannie Sherr, Lola Asseof and Lilly Fulop. Izraeli lab is supported by Department of Defense (W81XWH-15-1-0227), Israel Science Foundation, Giorgio \& Donna Shapiro and the Dotan centers for hematological malignancies at Tel Aviv University. EH is incumbent of the Mondry Family Professorial Chair and the Hornstein lab is supported by Dr. Sydney Brenner.",
year = "2017",
month = nov,
day = "30",
doi = "10.3324/haematol.2017.171736",
language = "الإنجليزيّة",
volume = "102",
pages = "476--480",
journal = "Haematologica",
issn = "0390-6078",
publisher = "Ferrata Storti Foundation",
number = "12",
}