Abstract
BACKGROUND: Dynamic mechanical allodynia (DMA) is both a symptom and a central sensitization sign, yet no standardized method for quantifying the DMA area has been reported. This study aimed to establish psychometric properties for Quantitative Dynamic Allodynography ( QDA), a newly developed protocol measuring the DMA area as a percentage of the body surface.
METHODS: Seventy-eight patients aged 18-65 diagnosed with chronic complex regional pain syndrome (CRPS) participated in this study. Test-retest reliability was conducted twice, one week apart (N = 20), and inter-rater (N = 3) reliability was conducted on 10 participants. Disease severity ( CRPS Severity Score, CSS), pain intensity (VAS), and quality of life (SF-36) measures were utilized to test construct validity.
RESULTS: High inter-rater reliability (intraclass correlation coefficient (ICC) = 0.96, p < 0.001) and test-retest reliability ( r = 0.98, p < 0.001) were found. Furthermore, the QDA score was found to be correlated with the CSS ( r = 0.47, p < 0.001), VAS ( r = 0.37, p < 0.001), and the SF-36 physical health total ( r = -0.47, p < 0.001) scores.
CONCLUSION: The QDA is the first developed reliable and valid protocol for measuring DMA in a clinical setting and may be used as a diagnostic and prognostic measure in clinics and in research, advancing the pain precision medicine approach.
| Original language | American English |
|---|---|
| Article number | 7949 |
| Journal | Sensors |
| Volume | 23 |
| Issue number | 18 |
| DOIs | |
| State | Published - Sep 2023 |
Keywords
- Chronic Pain/diagnosis
- Complex Regional Pain Syndromes
- Humans
- Hyperalgesia/diagnosis
- Quality of Life
- Reproducibility of Results
- central sensitization
- clinical pain
- mechanical allodynia
All Science Journal Classification (ASJC) codes
- Analytical Chemistry
- Information Systems
- Instrumentation
- Atomic and Molecular Physics, and Optics
- Electrical and Electronic Engineering
- Biochemistry