Quantifying continuous-flow dielectrophoretic trapping of cells and micro-particles on micro-electrode array

Lichen Rozitsky; Amir Fine; Dekel Dado; Shahar Nussbaum-Ben-Shaul; Shulamit Levenberg; Gilad Yossifon

doi:https://doi.org/10.1007/s10544-013-9773-9

Quantifying continuous-flow dielectrophoretic trapping of cells and micro-particles on micro-electrode array

Lichen Rozitsky, Amir Fine, Dekel Dado, Shahar Nussbaum-Ben-Shaul, Shulamit Levenberg, Gilad Yossifon

Technion - Israel Institute of Technology

Research output: Contribution to journal › Article › peer-review

Abstract

An interdigitated electrode array embedded within a micro-channel with forced flow is shown to enable dielectrophoretic (DEP) characterization of particles and/or cells based on measurements of their trapping percentage over a continuous frequency range. A simplified model of the trapping percentage, using spatial averaging of the convective and DEP force, linearly correlated it to the effective DEP force (in its positive mode). Thus, the Clausius-Mossotti factor was fitted to the experimental data, yielding effective electrical characteristics of the particles and/or cells. Also, the generated trapping percentage curve response over a continuous range of frequencies facilitates sorting and detection based on differences other than just the cross-over frequencies.

Original language	English
Pages (from-to)	859-865
Number of pages	7
Journal	Biomedical Microdevices
Volume	15
Issue number	5
DOIs	https://doi.org/10.1007/s10544-013-9773-9
State	Published - Oct 2013

Keywords

Dielectrophoresis
Microelectrodes
Microfluidics

All Science Journal Classification (ASJC) codes

Biomedical Engineering
Molecular Biology

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https://doi.org/10.1007/s10544-013-9773-9

Cite this

@article{e630a86ac63a44fd858a46c666c86f28,

title = "Quantifying continuous-flow dielectrophoretic trapping of cells and micro-particles on micro-electrode array",

abstract = "An interdigitated electrode array embedded within a micro-channel with forced flow is shown to enable dielectrophoretic (DEP) characterization of particles and/or cells based on measurements of their trapping percentage over a continuous frequency range. A simplified model of the trapping percentage, using spatial averaging of the convective and DEP force, linearly correlated it to the effective DEP force (in its positive mode). Thus, the Clausius-Mossotti factor was fitted to the experimental data, yielding effective electrical characteristics of the particles and/or cells. Also, the generated trapping percentage curve response over a continuous range of frequencies facilitates sorting and detection based on differences other than just the cross-over frequencies.",

keywords = "Dielectrophoresis, Microelectrodes, Microfluidics",

author = "Lichen Rozitsky and Amir Fine and Dekel Dado and Shahar Nussbaum-Ben-Shaul and Shulamit Levenberg and Gilad Yossifon",

note = "Funding Information: Acknowledgments The research was supported by MOST – Tashtiyot grant #880011. The fabrication of the chip was possible through the financial and technical support of the Technion RBNI (Russell Berrie Nanotechnology Institute) and MNFU (Micro Nano Fabrication Unit). We wish to acknowledge Yoni Shemesh, Vitali Plaei, Alicia Boymelgreen and Yoav Green for their valuable input.",

year = "2013",

month = oct,

doi = "https://doi.org/10.1007/s10544-013-9773-9",

language = "الإنجليزيّة",

volume = "15",

pages = "859--865",

journal = "Biomedical Microdevices",

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publisher = "Kluwer Academic Publishers",

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TY - JOUR

T1 - Quantifying continuous-flow dielectrophoretic trapping of cells and micro-particles on micro-electrode array

AU - Rozitsky, Lichen

AU - Fine, Amir

AU - Dado, Dekel

AU - Nussbaum-Ben-Shaul, Shahar

AU - Levenberg, Shulamit

AU - Yossifon, Gilad

N1 - Funding Information: Acknowledgments The research was supported by MOST – Tashtiyot grant #880011. The fabrication of the chip was possible through the financial and technical support of the Technion RBNI (Russell Berrie Nanotechnology Institute) and MNFU (Micro Nano Fabrication Unit). We wish to acknowledge Yoni Shemesh, Vitali Plaei, Alicia Boymelgreen and Yoav Green for their valuable input.

PY - 2013/10

Y1 - 2013/10

N2 - An interdigitated electrode array embedded within a micro-channel with forced flow is shown to enable dielectrophoretic (DEP) characterization of particles and/or cells based on measurements of their trapping percentage over a continuous frequency range. A simplified model of the trapping percentage, using spatial averaging of the convective and DEP force, linearly correlated it to the effective DEP force (in its positive mode). Thus, the Clausius-Mossotti factor was fitted to the experimental data, yielding effective electrical characteristics of the particles and/or cells. Also, the generated trapping percentage curve response over a continuous range of frequencies facilitates sorting and detection based on differences other than just the cross-over frequencies.

AB - An interdigitated electrode array embedded within a micro-channel with forced flow is shown to enable dielectrophoretic (DEP) characterization of particles and/or cells based on measurements of their trapping percentage over a continuous frequency range. A simplified model of the trapping percentage, using spatial averaging of the convective and DEP force, linearly correlated it to the effective DEP force (in its positive mode). Thus, the Clausius-Mossotti factor was fitted to the experimental data, yielding effective electrical characteristics of the particles and/or cells. Also, the generated trapping percentage curve response over a continuous range of frequencies facilitates sorting and detection based on differences other than just the cross-over frequencies.

KW - Dielectrophoresis

KW - Microelectrodes

KW - Microfluidics

UR - http://www.scopus.com/inward/record.url?scp=84884321930&partnerID=8YFLogxK

U2 - https://doi.org/10.1007/s10544-013-9773-9

DO - https://doi.org/10.1007/s10544-013-9773-9

M3 - مقالة

C2 - 23690092

SN - 1387-2176

VL - 15

SP - 859

EP - 865

JO - Biomedical Microdevices

JF - Biomedical Microdevices

IS - 5

ER -

Quantifying continuous-flow dielectrophoretic trapping of cells and micro-particles on micro-electrode array

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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