Pseudomonas aeruginosa activates the quorum sensing LuxR response regulator through secretion of 2-aminoacetophenone

I. Kviatkovski; L. Chernin; T. Yarnitzky; I. Frumin; N. Sobel; Y. Helman

doi:10.1039/c4cc10393a

Pseudomonas aeruginosa activates the quorum sensing LuxR response regulator through secretion of 2-aminoacetophenone

I. Kviatkovski, L. Chernin, T. Yarnitzky, I. Frumin, N. Sobel, Y. Helman

The Hebrew University of Jerusalem, Weizmann Institute of Science

Research output: Contribution to journal › Article › peer-review

Abstract

In this study we identify a volatile compound produced by Pseudomonas aeruginosa, which can specifically activate the LuxR quorum-sensing response regulator of Vibrio fischeri. Comparative gas-chromatography analysis between P. aeruginosa wild type and a ΔlasR mutant strain implied that the active volatile is 2-aminoacetophenone. The use of synthetic 2-aminoacetophenone and in silico docking analyses verified the activity of the molecule and provided putative interacting residues within the binding site.

Original language	English
Pages (from-to)	3258-3261
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	15
DOIs	https://doi.org/10.1039/c4cc10393a
State	Published - 21 Feb 2015

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
General Chemistry
Ceramics and Composites
Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
Catalysis

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title = "Pseudomonas aeruginosa activates the quorum sensing LuxR response regulator through secretion of 2-aminoacetophenone",

abstract = "In this study we identify a volatile compound produced by Pseudomonas aeruginosa, which can specifically activate the LuxR quorum-sensing response regulator of Vibrio fischeri. Comparative gas-chromatography analysis between P. aeruginosa wild type and a ΔlasR mutant strain implied that the active volatile is 2-aminoacetophenone. The use of synthetic 2-aminoacetophenone and in silico docking analyses verified the activity of the molecule and provided putative interacting residues within the binding site.",

author = "I. Kviatkovski and L. Chernin and T. Yarnitzky and I. Frumin and N. Sobel and Y. Helman",

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AU - Kviatkovski, I.

AU - Chernin, L.

AU - Yarnitzky, T.

AU - Frumin, I.

AU - Sobel, N.

AU - Helman, Y.

PY - 2015/2/21

Y1 - 2015/2/21

N2 - In this study we identify a volatile compound produced by Pseudomonas aeruginosa, which can specifically activate the LuxR quorum-sensing response regulator of Vibrio fischeri. Comparative gas-chromatography analysis between P. aeruginosa wild type and a ΔlasR mutant strain implied that the active volatile is 2-aminoacetophenone. The use of synthetic 2-aminoacetophenone and in silico docking analyses verified the activity of the molecule and provided putative interacting residues within the binding site.

AB - In this study we identify a volatile compound produced by Pseudomonas aeruginosa, which can specifically activate the LuxR quorum-sensing response regulator of Vibrio fischeri. Comparative gas-chromatography analysis between P. aeruginosa wild type and a ΔlasR mutant strain implied that the active volatile is 2-aminoacetophenone. The use of synthetic 2-aminoacetophenone and in silico docking analyses verified the activity of the molecule and provided putative interacting residues within the binding site.

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U2 - 10.1039/c4cc10393a

DO - 10.1039/c4cc10393a

M3 - مقالة

C2 - 25614099

SN - 1359-7345

VL - 51

SP - 3258

EP - 3261

JO - Chemical Communications

JF - Chemical Communications

IS - 15

ER -

Pseudomonas aeruginosa activates the quorum sensing LuxR response regulator through secretion of 2-aminoacetophenone

Abstract

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