Proteomics of Melanoma Response to Immunotherapy Reveals Mitochondrial Dependence

Michal Harel; Rona Ortenberg; Siva Karthik Varanasi; Kailash Chandra Mangalhara; Mariya Mardamshina; Ettai Markovits; Erez N Baruch; Victoria Tripple; May Arama-Chayoth; Eyal Greenberg; Anjana Shenoy; Ruveyda Ayasun; Naama Knafo; Shihao Xu; Liat Anafi; Gali Yanovich-Arad; Georgina D Barnabas; Shira Ashkenazi; Michal J Besser; Jacob Schachter; Marcus Bosenberg; Gerald S Shadel; Iris Barshack; Susan M Kaech; Gal Markel; Tamar Geiger

doi:10.1016/j.cell.2019.08.012

Proteomics of Melanoma Response to Immunotherapy Reveals Mitochondrial Dependence

Michal Harel, Rona Ortenberg, Siva Karthik Varanasi, Kailash Chandra Mangalhara, Mariya Mardamshina, Ettai Markovits, Erez N Baruch, Victoria Tripple, May Arama-Chayoth, Eyal Greenberg, Anjana Shenoy, Ruveyda Ayasun, Naama Knafo, Shihao Xu, Liat Anafi, Gali Yanovich-Arad, Georgina D Barnabas, Shira Ashkenazi, Michal J Besser, Jacob SchachterMarcus Bosenberg, Gerald S Shadel, Iris Barshack, Susan M Kaech, Gal Markel, Tamar Geiger

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

Abstract

Proteomic profiling of melanomas from patients undergoing immunotherapy reveals key mediators of tumor immunogenicity.

Original language	English
Pages (from-to)	236-250.e18
Journal	Cell
Volume	179
Issue number	1
DOIs	https://doi.org/10.1016/j.cell.2019.08.012
State	Published - 19 Sep 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

anti-PD-1
cancer metabolism
immune checkpoint inhibitors
immunotherapy
lipid metabolism
mass spectrometry
melanoma
mitochondrial metabolism
proteomics
tumor-infiltrating lymphocytes

All Science Journal Classification (ASJC) codes

General Biochemistry,Genetics and Molecular Biology

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Harel, M., Ortenberg, R., Varanasi, S. K., Mangalhara, K. C., Mardamshina, M., Markovits, E., Baruch, E. N., Tripple, V., Arama-Chayoth, M., Greenberg, E., Shenoy, A., Ayasun, R., Knafo, N., Xu, S., Anafi, L., Yanovich-Arad, G., Barnabas, G. D., Ashkenazi, S., Besser, M. J., ... Geiger, T. (2019). Proteomics of Melanoma Response to Immunotherapy Reveals Mitochondrial Dependence. Cell, 179(1), 236-250.e18. https://doi.org/10.1016/j.cell.2019.08.012

@article{07429458697545199ba37f4c806a2eb4,

title = "Proteomics of Melanoma Response to Immunotherapy Reveals Mitochondrial Dependence",

abstract = "Proteomic profiling of melanomas from patients undergoing immunotherapy reveals key mediators of tumor immunogenicity.",

keywords = "anti-PD-1, cancer metabolism, immune checkpoint inhibitors, immunotherapy, lipid metabolism, mass spectrometry, melanoma, mitochondrial metabolism, proteomics, tumor-infiltrating lymphocytes",

author = "Michal Harel and Rona Ortenberg and Varanasi, \{Siva Karthik\} and Mangalhara, \{Kailash Chandra\} and Mariya Mardamshina and Ettai Markovits and Baruch, \{Erez N\} and Victoria Tripple and May Arama-Chayoth and Eyal Greenberg and Anjana Shenoy and Ruveyda Ayasun and Naama Knafo and Shihao Xu and Liat Anafi and Gali Yanovich-Arad and Barnabas, \{Georgina D\} and Shira Ashkenazi and Besser, \{Michal J\} and Jacob Schachter and Marcus Bosenberg and Shadel, \{Gerald S\} and Iris Barshack and Kaech, \{Susan M\} and Gal Markel and Tamar Geiger",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = sep,

day = "19",

doi = "10.1016/j.cell.2019.08.012",

language = "الإنجليزيّة",

volume = "179",

pages = "236--250.e18",

journal = "Cell",

issn = "0092-8674",

publisher = "Elsevier B.V.",

number = "1",

}

Harel, M, Ortenberg, R, Varanasi, SK, Mangalhara, KC, Mardamshina, M, Markovits, E, Baruch, EN, Tripple, V, Arama-Chayoth, M, Greenberg, E, Shenoy, A, Ayasun, R, Knafo, N, Xu, S, Anafi, L, Yanovich-Arad, G, Barnabas, GD, Ashkenazi, S, Besser, MJ, Schachter, J, Bosenberg, M, Shadel, GS, Barshack, I, Kaech, SM, Markel, G & Geiger, T 2019, 'Proteomics of Melanoma Response to Immunotherapy Reveals Mitochondrial Dependence', Cell, vol. 179, no. 1, pp. 236-250.e18. https://doi.org/10.1016/j.cell.2019.08.012

TY - JOUR

T1 - Proteomics of Melanoma Response to Immunotherapy Reveals Mitochondrial Dependence

AU - Harel, Michal

AU - Ortenberg, Rona

AU - Varanasi, Siva Karthik

AU - Mangalhara, Kailash Chandra

AU - Mardamshina, Mariya

AU - Markovits, Ettai

AU - Baruch, Erez N

AU - Tripple, Victoria

AU - Arama-Chayoth, May

AU - Greenberg, Eyal

AU - Shenoy, Anjana

AU - Ayasun, Ruveyda

AU - Knafo, Naama

AU - Xu, Shihao

AU - Anafi, Liat

AU - Yanovich-Arad, Gali

AU - Barnabas, Georgina D

AU - Ashkenazi, Shira

AU - Besser, Michal J

AU - Schachter, Jacob

AU - Bosenberg, Marcus

AU - Shadel, Gerald S

AU - Barshack, Iris

AU - Kaech, Susan M

AU - Markel, Gal

AU - Geiger, Tamar

PY - 2019/9/19

Y1 - 2019/9/19

N2 - Proteomic profiling of melanomas from patients undergoing immunotherapy reveals key mediators of tumor immunogenicity.

AB - Proteomic profiling of melanomas from patients undergoing immunotherapy reveals key mediators of tumor immunogenicity.

KW - anti-PD-1

KW - cancer metabolism

KW - immune checkpoint inhibitors

KW - immunotherapy

KW - lipid metabolism

KW - mass spectrometry

KW - melanoma

KW - mitochondrial metabolism

KW - proteomics

KW - tumor-infiltrating lymphocytes

UR - http://www.scopus.com/inward/record.url?scp=85072162948&partnerID=8YFLogxK

U2 - 10.1016/j.cell.2019.08.012

DO - 10.1016/j.cell.2019.08.012

M3 - مقالة

C2 - 31495571

SN - 0092-8674

VL - 179

SP - 236-250.e18

JO - Cell

JF - Cell

IS - 1

ER -

Proteomics of Melanoma Response to Immunotherapy Reveals Mitochondrial Dependence

Abstract

UN SDGs

Keywords

All Science Journal Classification (ASJC) codes

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