Proteome-wide mapping of PQS-interacting proteins in: Pseudomonas aeruginosa

Rambabu Dandela; Danielle Mantin; Benjamin F. Cravatt; Josep Rayo; Michael M. Meijler

doi:10.1039/c7sc04287f

Proteome-wide mapping of PQS-interacting proteins in: Pseudomonas aeruginosa

Rambabu Dandela, Danielle Mantin, Benjamin F. Cravatt, Josep Rayo, Michael M. Meijler

Department of Chemistry

Ben-Gurion University of the Negev

Research output: Contribution to journal › Article › peer-review

Abstract

The opportunistic human pathogen Pseudomonas aeruginosa secretes 2-heptyl-3-hydroxy-4-quinolone (PQS), a quorum sensing (QS) signal that regulates the expression of numerous virulence genes. Here we report the development and application of chemical probes to globally map quinolone binding proteins. The revealed quinolone interactome contains both known as well as newly identified virulence factors and presents new targets for the treatment of bacterial infections.

Original language	American English
Pages (from-to)	2290-2294
Number of pages	5
Journal	Chemical Science
Volume	9
Issue number	8
DOIs	https://doi.org/10.1039/c7sc04287f
State	Published - 1 Jan 2018

All Science Journal Classification (ASJC) codes

General Chemistry

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10.1039/c7sc04287f

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abstract = "The opportunistic human pathogen Pseudomonas aeruginosa secretes 2-heptyl-3-hydroxy-4-quinolone (PQS), a quorum sensing (QS) signal that regulates the expression of numerous virulence genes. Here we report the development and application of chemical probes to globally map quinolone binding proteins. The revealed quinolone interactome contains both known as well as newly identified virulence factors and presents new targets for the treatment of bacterial infections.",

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Proteome-wide mapping of PQS-interacting proteins in: Pseudomonas aeruginosa

Abstract

All Science Journal Classification (ASJC) codes

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