Protein tyrosine phosphatases in health and disease

Wiljan J. A. J. Hendriks; Ari Elson; Sheila Harroch; Rafael Pulido; Andrew Stoker; Jeroen den Hertog

doi:https://doi.org/10.1111/febs.12000

Protein tyrosine phosphatases in health and disease

Wiljan J. A. J. Hendriks, Ari Elson, Sheila Harroch, Rafael Pulido, Andrew Stoker, Jeroen den Hertog

Department of Molecular Genetics

Weizmann Institute of Science

Research output: Contribution to journal › Review article › peer-review

Abstract

Protein tyrosine phosphatases (PTPs) represent a super-family of enzymes that play essential roles in normal development and physiology. In this review, we will discuss the PTPs that have a causative role in hereditary diseases in humans. In addition, recent progress in the development and analysis of animal models expressing mutant PTPs will be presented. The impact of PTP signaling on health and disease will be exemplified for the fields of bone development, synaptogenesis and central nervous system diseases. Collectively, research on PTPs since the late 1980's yielded the cogent view that development of PTP-directed therapeutic tools is essential to further combat human disease.

Original language	English
Pages (from-to)	708-730
Number of pages	23
Journal	FEBS Journal
Volume	280
Issue number	2
DOIs	https://doi.org/10.1111/febs.12000
State	Published - Jan 2013

All Science Journal Classification (ASJC) codes

Molecular Biology
Biochemistry
Cell Biology

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https://doi.org/10.1111/febs.12000

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title = "Protein tyrosine phosphatases in health and disease",

abstract = "Protein tyrosine phosphatases (PTPs) represent a super-family of enzymes that play essential roles in normal development and physiology. In this review, we will discuss the PTPs that have a causative role in hereditary diseases in humans. In addition, recent progress in the development and analysis of animal models expressing mutant PTPs will be presented. The impact of PTP signaling on health and disease will be exemplified for the fields of bone development, synaptogenesis and central nervous system diseases. Collectively, research on PTPs since the late 1980's yielded the cogent view that development of PTP-directed therapeutic tools is essential to further combat human disease.",

author = "Hendriks, {Wiljan J. A. J.} and Ari Elson and Sheila Harroch and Rafael Pulido and Andrew Stoker and {den Hertog}, Jeroen",

note = "European Union; European Research Community [MRTN-CT-2006-035830]The authors were all associated with PTPNET, a European Union-funded Marie Curie Research Training Network that ran from 2007 to 2011. This review is the direct result of our collaborative efforts within PTPNET. We apologize to all colleagues whose original work could not be referred to because of space constraints. We would like to thank PTPNET members Charlotte Coles and Radu Aricescu for constructive criticism of this review article. This work was supported in part by European Research Community Funds to PTPNET (MRTN-CT-2006-035830).",

year = "2013",

month = jan,

doi = "https://doi.org/10.1111/febs.12000",

language = "الإنجليزيّة",

volume = "280",

pages = "708--730",

journal = "FEBS Journal",

issn = "1742-464X",

publisher = "John Wiley and Sons Inc.",

number = "2",

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T1 - Protein tyrosine phosphatases in health and disease

AU - Hendriks, Wiljan J. A. J.

AU - Elson, Ari

AU - Harroch, Sheila

AU - Pulido, Rafael

AU - Stoker, Andrew

AU - den Hertog, Jeroen

N1 - European Union; European Research Community [MRTN-CT-2006-035830]The authors were all associated with PTPNET, a European Union-funded Marie Curie Research Training Network that ran from 2007 to 2011. This review is the direct result of our collaborative efforts within PTPNET. We apologize to all colleagues whose original work could not be referred to because of space constraints. We would like to thank PTPNET members Charlotte Coles and Radu Aricescu for constructive criticism of this review article. This work was supported in part by European Research Community Funds to PTPNET (MRTN-CT-2006-035830).

PY - 2013/1

Y1 - 2013/1

N2 - Protein tyrosine phosphatases (PTPs) represent a super-family of enzymes that play essential roles in normal development and physiology. In this review, we will discuss the PTPs that have a causative role in hereditary diseases in humans. In addition, recent progress in the development and analysis of animal models expressing mutant PTPs will be presented. The impact of PTP signaling on health and disease will be exemplified for the fields of bone development, synaptogenesis and central nervous system diseases. Collectively, research on PTPs since the late 1980's yielded the cogent view that development of PTP-directed therapeutic tools is essential to further combat human disease.

AB - Protein tyrosine phosphatases (PTPs) represent a super-family of enzymes that play essential roles in normal development and physiology. In this review, we will discuss the PTPs that have a causative role in hereditary diseases in humans. In addition, recent progress in the development and analysis of animal models expressing mutant PTPs will be presented. The impact of PTP signaling on health and disease will be exemplified for the fields of bone development, synaptogenesis and central nervous system diseases. Collectively, research on PTPs since the late 1980's yielded the cogent view that development of PTP-directed therapeutic tools is essential to further combat human disease.

UR - http://www.scopus.com/inward/record.url?scp=84872772147&partnerID=8YFLogxK

U2 - https://doi.org/10.1111/febs.12000

DO - https://doi.org/10.1111/febs.12000

M3 - مقالة مرجعية

SN - 1742-464X

VL - 280

SP - 708

EP - 730

JO - FEBS Journal

JF - FEBS Journal

IS - 2

ER -

Protein tyrosine phosphatases in health and disease

Abstract

All Science Journal Classification (ASJC) codes

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