Protein-Protein Communication and Enzyme Activation Mediated by a Synthetic Chemical Transducer

Ronny Peri-Naor, Tal Ilani, Leila Motiei, David Margulies

Research output: Contribution to journalArticlepeer-review


The design and function of A synthetic "chemical transducer" that can generate an unnatural communication channel between two proteins is described. Specifically, we show how this transducer enables platelet-derived growth factor to trigger (in vitro) the catalytic activity of glutathione-s-transferase (GST), which is not Its natural enzyme partner. GST activity can be further controlled by adding specific oligonucleotides that switch the enzymatic reaction: on and off: We also demonstrate that a molecular machine, which can regulate the function of an enzyme, could be used to change the way a prodrug is activated in a "programmable" manner.

Original languageEnglish
Pages (from-to)9507-9510
Number of pages4
JournalJournal of the American Chemical Society
Issue number30
StatePublished - 5 Aug 2015

All Science Journal Classification (ASJC) codes

  • General Chemistry
  • Biochemistry
  • Catalysis
  • Colloid and Surface Chemistry


Dive into the research topics of 'Protein-Protein Communication and Enzyme Activation Mediated by a Synthetic Chemical Transducer'. Together they form a unique fingerprint.

Cite this