Protecting Proteins from Desiccation Stress Using Molecular Glasses and Gels

Gil I. Olgenblum, Brent O. Hutcheson, Gary J. Pielak, Daniel Harries

Research output: Contribution to journalReview articlepeer-review


Faced with desiccation stress, many organisms deploy strategies to maintain the integrity of their cellular components. Amorphous glassy media composed of small molecular solutes or protein gels present general strategies for protecting against drying. We review these strategies and the proposed molecular mechanisms to explain protein protection in a vitreous matrix under conditions of low hydration. We also describe efforts to exploit similar strategies in technological applications for protecting proteins in dry or highly desiccated states. Finally, we outline open questions and possibilities for future explorations.

Original languageAmerican English
Pages (from-to)5668-5694
Number of pages27
JournalChemical Reviews
Issue number9
StatePublished - 8 May 2024

All Science Journal Classification (ASJC) codes

  • General Chemistry


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