TY - JOUR
T1 - Prospective association of polycystic ovary syndrome with coronary artery calcification and carotid-intima-media thickness the coronary artery risk development in young adults women's study
AU - Calderon-Margalit, Ronit
AU - Siscovick, David
AU - Merkin, Sharon S.
AU - Wang, Erica
AU - Daviglus, Martha L.
AU - Schreiner, Pamela J.
AU - Sternfeld, Barbara
AU - Dale Williams, O.
AU - Lewis, Cora E.
AU - Azziz, Ricardo
AU - Schwartz, Stephen M.
AU - Wellons, Melissa F.
N1 - Publisher Copyright: © 2014 American Heart Association, Inc.
PY - 2014/12/11
Y1 - 2014/12/11
N2 - Objective-To study the independent associations of polycystic ovary syndrome (PCOS), and its 2 components, hyperandrogenism and anovulation, with coronary artery calcification (CAC) and carotid artery intima-media thickness (IMT).Approach and Results-At the year 20 of the Coronary Artery Risk Development in Young Adults (CARDIA) study, a population-based multicenter cohort of young adults, women (mean age, 45 years) with information on menses and hirsutism in their twenties were assessed for CAC (n=982) and IMT (n=988). We defined PCOS as women who had both irregular menses and hyperandrogenism (n=55); isolated oligomenorrhea (n=103) as women who only had irregular menses; and isolated hyperandrogenism (n=156) as women who had either hirsutism or increased testosterone levels. Logistic regressions and general linear models were used to estimate the associations between components of PCOS and subclinical CVD. The prevalence of CAC was 10.3% overall. Women with PCOS had a multivariable adjusted odds ratio of 2.70 (95% confidence interval, 1.31-5.60) for CAC. Women with either isolated oligomenorrhea or isolated hyperandrogenism had no increased risk of CAC when compared with unexposed women. Women with PCOS had significantly increased bulb and internal carotid-IMT measurements; however, no significant differences were noted in bulb or internal carotid artery IMT among women with either isolated oligomenorrhea or isolated hyperandrogenism when compared with unexposed women. There were no differences in common carotid-IMT among the 4 study groups.Conclusions-In this study, women with PCOS, manifested as both anovulation and hyperandrogenism, but not women with one of these manifestations alone, were at increased risk for the development of subclinical CVD.
AB - Objective-To study the independent associations of polycystic ovary syndrome (PCOS), and its 2 components, hyperandrogenism and anovulation, with coronary artery calcification (CAC) and carotid artery intima-media thickness (IMT).Approach and Results-At the year 20 of the Coronary Artery Risk Development in Young Adults (CARDIA) study, a population-based multicenter cohort of young adults, women (mean age, 45 years) with information on menses and hirsutism in their twenties were assessed for CAC (n=982) and IMT (n=988). We defined PCOS as women who had both irregular menses and hyperandrogenism (n=55); isolated oligomenorrhea (n=103) as women who only had irregular menses; and isolated hyperandrogenism (n=156) as women who had either hirsutism or increased testosterone levels. Logistic regressions and general linear models were used to estimate the associations between components of PCOS and subclinical CVD. The prevalence of CAC was 10.3% overall. Women with PCOS had a multivariable adjusted odds ratio of 2.70 (95% confidence interval, 1.31-5.60) for CAC. Women with either isolated oligomenorrhea or isolated hyperandrogenism had no increased risk of CAC when compared with unexposed women. Women with PCOS had significantly increased bulb and internal carotid-IMT measurements; however, no significant differences were noted in bulb or internal carotid artery IMT among women with either isolated oligomenorrhea or isolated hyperandrogenism when compared with unexposed women. There were no differences in common carotid-IMT among the 4 study groups.Conclusions-In this study, women with PCOS, manifested as both anovulation and hyperandrogenism, but not women with one of these manifestations alone, were at increased risk for the development of subclinical CVD.
KW - Carotid intima media thickness
KW - Cohort studies
KW - Coronary atherosclerosis
KW - Electron beam computed tomography
KW - Polycystic Ovary Syndrome
KW - Risk
UR - http://www.scopus.com/inward/record.url?scp=84918797604&partnerID=8YFLogxK
U2 - https://doi.org/10.1161/ATVBAHA.114.304136
DO - https://doi.org/10.1161/ATVBAHA.114.304136
M3 - مقالة
C2 - 25359859
SN - 1079-5642
VL - 34
SP - 2688
EP - 2694
JO - Arteriosclerosis, Thrombosis, and Vascular Biology
JF - Arteriosclerosis, Thrombosis, and Vascular Biology
IS - 12
ER -