Programming Bacteriophages by Swapping Their Specificity Determinants

Moran G. Goren; Ido Yosef; Udi Qimron

doi:10.1016/j.tim.2015.10.006

Programming Bacteriophages by Swapping Their Specificity Determinants

Moran G. Goren, Ido Yosef, Udi Qimron

Tel Aviv University

Research output: Contribution to journal › Short survey › peer-review

Abstract

Bacteriophages, bacteria's natural enemies, may serve as potent antibacterial agents. Their specificity for certain bacterial sub-species limits their effectiveness, but allows selective targeting of bacteria. Lu and colleagues present a platform for such targeting through alteration of bacteriophages' host specificity by swapping specificity domains in their host-recognition ligand.

Original language	American English
Pages (from-to)	744-746
Number of pages	3
Journal	Trends in Microbiology
Volume	23
Issue number	12
DOIs	https://doi.org/10.1016/j.tim.2015.10.006
State	Published - 1 Jan 2015

Keywords

Bacteriophage adsorption
Host-range expansion
Host-recognition ligand
Shaping bacterial microbiome

All Science Journal Classification (ASJC) codes

Microbiology
Microbiology (medical)
Virology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tim.2015.10.006

Cite this

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title = "Programming Bacteriophages by Swapping Their Specificity Determinants",

abstract = "Bacteriophages, bacteria's natural enemies, may serve as potent antibacterial agents. Their specificity for certain bacterial sub-species limits their effectiveness, but allows selective targeting of bacteria. Lu and colleagues present a platform for such targeting through alteration of bacteriophages' host specificity by swapping specificity domains in their host-recognition ligand.",

keywords = "Bacteriophage adsorption, Host-range expansion, Host-recognition ligand, Shaping bacterial microbiome",

author = "Goren, {Moran G.} and Ido Yosef and Udi Qimron",

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year = "2015",

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AU - Goren, Moran G.

AU - Yosef, Ido

AU - Qimron, Udi

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Bacteriophages, bacteria's natural enemies, may serve as potent antibacterial agents. Their specificity for certain bacterial sub-species limits their effectiveness, but allows selective targeting of bacteria. Lu and colleagues present a platform for such targeting through alteration of bacteriophages' host specificity by swapping specificity domains in their host-recognition ligand.

AB - Bacteriophages, bacteria's natural enemies, may serve as potent antibacterial agents. Their specificity for certain bacterial sub-species limits their effectiveness, but allows selective targeting of bacteria. Lu and colleagues present a platform for such targeting through alteration of bacteriophages' host specificity by swapping specificity domains in their host-recognition ligand.

KW - Bacteriophage adsorption

KW - Host-range expansion

KW - Host-recognition ligand

KW - Shaping bacterial microbiome

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U2 - 10.1016/j.tim.2015.10.006

DO - 10.1016/j.tim.2015.10.006

M3 - Short survey

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SN - 0966-842X

VL - 23

SP - 744

EP - 746

JO - Trends in Microbiology

JF - Trends in Microbiology

IS - 12

ER -

Programming Bacteriophages by Swapping Their Specificity Determinants

Abstract

Keywords

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

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