Programming Bacteriophages by Swapping Their Specificity Determinants

Moran G. Goren; Ido Yosef; Udi Qimron

doi:10.1016/j.tim.2015.10.006

Programming Bacteriophages by Swapping Their Specificity Determinants

Moran G. Goren, Ido Yosef, Udi Qimron

Clinical Microbiology and Immunology

Tel Aviv University

Research output: Contribution to journal › Short survey › peer-review

Abstract

Bacteriophages, bacteria's natural enemies, may serve as potent antibacterial agents. Their specificity for certain bacterial sub-species limits their effectiveness, but allows selective targeting of bacteria. Lu and colleagues present a platform for such targeting through alteration of bacteriophages' host specificity by swapping specificity domains in their host-recognition ligand.

Original language	American English
Pages (from-to)	744-746
Number of pages	3
Journal	Trends in Microbiology
Volume	23
Issue number	12
DOIs	https://doi.org/10.1016/j.tim.2015.10.006
State	Published - 1 Jan 2015

Keywords

Bacteriophage adsorption
Host-range expansion
Host-recognition ligand
Shaping bacterial microbiome

All Science Journal Classification (ASJC) codes

Microbiology
Microbiology (medical)
Virology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.tim.2015.10.006

Cite this

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title = "Programming Bacteriophages by Swapping Their Specificity Determinants",

abstract = "Bacteriophages, bacteria's natural enemies, may serve as potent antibacterial agents. Their specificity for certain bacterial sub-species limits their effectiveness, but allows selective targeting of bacteria. Lu and colleagues present a platform for such targeting through alteration of bacteriophages' host specificity by swapping specificity domains in their host-recognition ligand.",

keywords = "Bacteriophage adsorption, Host-range expansion, Host-recognition ligand, Shaping bacterial microbiome",

author = "Goren, {Moran G.} and Ido Yosef and Udi Qimron",

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year = "2015",

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AU - Goren, Moran G.

AU - Yosef, Ido

AU - Qimron, Udi

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Y1 - 2015/1/1

N2 - Bacteriophages, bacteria's natural enemies, may serve as potent antibacterial agents. Their specificity for certain bacterial sub-species limits their effectiveness, but allows selective targeting of bacteria. Lu and colleagues present a platform for such targeting through alteration of bacteriophages' host specificity by swapping specificity domains in their host-recognition ligand.

AB - Bacteriophages, bacteria's natural enemies, may serve as potent antibacterial agents. Their specificity for certain bacterial sub-species limits their effectiveness, but allows selective targeting of bacteria. Lu and colleagues present a platform for such targeting through alteration of bacteriophages' host specificity by swapping specificity domains in their host-recognition ligand.

KW - Bacteriophage adsorption

KW - Host-range expansion

KW - Host-recognition ligand

KW - Shaping bacterial microbiome

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U2 - 10.1016/j.tim.2015.10.006

DO - 10.1016/j.tim.2015.10.006

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VL - 23

SP - 744

EP - 746

JO - Trends in Microbiology

JF - Trends in Microbiology

IS - 12

ER -

Programming Bacteriophages by Swapping Their Specificity Determinants

Abstract

Keywords

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

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