TY - JOUR
T1 - Primary peritoneal serous carcinoma in men
T2 - A rare and non-BRCA-associated entity
AU - Neuhausen, Susan L.
AU - Shani, Hagit
AU - Keinan Boker, Lital
AU - Steele, Linda
AU - Silverman, Barbara G.
AU - Ottini, Laura
AU - Silvestri, Valentina
AU - Laitman, Yael
AU - Korach, Jacob
AU - Perri, Tamar
AU - Friedman, Eitan
PY - 2017/6
Y1 - 2017/6
N2 - Background: Primary peritoneal serous carcinoma (PPSC) is a rare neoplasm. The paucity of reported cases among men may provide insight to the cell of origin of PPSC. Materials and Methods: A search for the ICD 0-3 code of PPSC (C48.2) in the following datasets: the Israeli National Cancer registry (INCR), the Surveillance, Epidemiology, and End Results (SEER) database in the USA, Israeli male BRCA carriers, male high-risk and BRCA carriers in a USA study, and the Italian Study on Male Breast Cancer (MBC) were performed. Results: In the INCR dataset, 220 entries for C48.2 code were noted, with only one male (male:female ratio=0.0045). In the SEER dataset for histology codes of papillary/serous/adenocarcinoma, 2,673 cases were recorded, with five males (male:female ratio=0.0018). None of the recorded US or Italian male BRCA carriers or MBC, or Israeli male BRCA carriers was diagnosed with PPSC. Conclusion: PPSC is a rare neoplasm, seemingly not associated with BRCA mutations in men, and fallopian tube epithelial cell implants may contribute to its development.
AB - Background: Primary peritoneal serous carcinoma (PPSC) is a rare neoplasm. The paucity of reported cases among men may provide insight to the cell of origin of PPSC. Materials and Methods: A search for the ICD 0-3 code of PPSC (C48.2) in the following datasets: the Israeli National Cancer registry (INCR), the Surveillance, Epidemiology, and End Results (SEER) database in the USA, Israeli male BRCA carriers, male high-risk and BRCA carriers in a USA study, and the Italian Study on Male Breast Cancer (MBC) were performed. Results: In the INCR dataset, 220 entries for C48.2 code were noted, with only one male (male:female ratio=0.0045). In the SEER dataset for histology codes of papillary/serous/adenocarcinoma, 2,673 cases were recorded, with five males (male:female ratio=0.0018). None of the recorded US or Italian male BRCA carriers or MBC, or Israeli male BRCA carriers was diagnosed with PPSC. Conclusion: PPSC is a rare neoplasm, seemingly not associated with BRCA mutations in men, and fallopian tube epithelial cell implants may contribute to its development.
KW - Cancer risk
KW - Male BRCA mutations
KW - Ovarian cancer
KW - PPSC
KW - Primary peritoneal serous carcinoma
UR - http://www.scopus.com/inward/record.url?scp=85019676649&partnerID=8YFLogxK
U2 - https://doi.org/10.21873/anticanres.11662
DO - https://doi.org/10.21873/anticanres.11662
M3 - Article
C2 - 28551646
SN - 0250-7005
VL - 37
SP - 3069
EP - 3072
JO - Anticancer Research
JF - Anticancer Research
IS - 6
ER -
