Previous abortion is a positive predictor for ongoing pregnancy in the next cycle in women with repeated IVF failures

Jigal Haas, Liat Lerner-Geva, Gil M. Yerushalmi, Ettie Maman, Yoav Yinon, Micha Baum, Ariel Hourvitz

Research output: Contribution to journalArticlepeer-review


Early pregnancy loss is common among women treated with assisted reproduction treatment, but whether it is a prognostic factor for success in subsequent IVF cycles is not well established. The aim of this study was to determine whether a biochemical pregnancy (BP) or spontaneous abortion (SA) affects the pregnancy rates in the following cycle. A retrospective study of 2687 women undergoing 6678 cycles between January 1998 and March 2010 was performed. Ongoing pregnancy rate (PR) per cycle was compared between patients with a pregnancy loss versus a negative β-HCG in their previous cycles. Multivariate analysis of factors affecting ongoing pregnancy rate was performed. BP and/or SA in the first three cycles did not significantly alter the chances to conceive (16.9% patients with BP and/or SA in the previous cycle versus 16.5% patients with no previous pregnancy). From cycle 4 onwards, the presence of a previous abortion (either BP or SA) was associated with better ongoing PR (23.0% versus 11.2%, P < 0.001). In conclusion, BP and/or SA in a previous cycle appears to be a positive marker for success in subsequent cycles in patients with repeated IVF failures. These results should be further investigated in this challenging group of patients.

Original languageEnglish
Pages (from-to)339-344
Number of pages6
JournalReproductive BioMedicine Online
Issue number4
StatePublished - Oct 2012


  • IVF
  • assisted reproduction
  • biochemical pregnancy
  • ongoing pregnancy rates
  • pregnancy loss
  • spontaneous abortion

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine
  • Obstetrics and Gynaecology
  • Developmental Biology


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