Preparation, structural characterization and cytotoxicity of hydrolytically stable Ti(IV) citrate complexes

Nathan Engelberg; Avi Bino; Edit Y. Tshuva

doi:10.1016/j.ica.2020.119429

Preparation, structural characterization and cytotoxicity of hydrolytically stable Ti(IV) citrate complexes

Nathan Engelberg, Avi Bino, Edit Y. Tshuva

Institute of Chemistry

The Hebrew University of Jerusalem

Research output: Contribution to journal › Article › peer-review

Abstract

Hydrolytically stable and water soluble Ti(IV) complexes can be used for various applications, including industrial, medicinal and more. Herein, a novel tetra-nuclear Ti(IV) complex with citrate ligands was obtained by reacting Ti(IV) isopropoxide and citric acid in an aqueous solution. The three dimensional structure of the complex [Ti₄O₆(Hcit)₃(cit)]⁹⁻ 1, as it appears in the compound [Co(NH₃)₆]₃[Ti₄O₆(Hcit)₃(cit)]⋅20H₂O was determined by single-crystal X-ray crystallography. Complex 1 possesses an adamantane-like {Ti₄O₆} core where each metal atom is coordinated to a tri-dentate citrate ligand with one dangling CH₂COOH group. An additional already known Ti(IV) complex [Ti(Hcit³⁻)₃]⁵⁻ 2 was synthesized for comparison. The high hydrolytic stability of complexes 1 and 2 has been substantiated based on NMR techniques. The cytotoxicity of the complexes was tested on three cancer cell lines: human ovarian A2780 and drug-resistant variants A2780cis and A2780ADR. Complex 1 showed a slight cytotoxicity towards the ovarian cells, while complex 2 was inactive.

Original language	English
Article number	119429
Journal	Inorganica Chimica Acta
Volume	503
DOIs	https://doi.org/10.1016/j.ica.2020.119429
State	Published - 1 Apr 2020

All Science Journal Classification (ASJC) codes

Physical and Theoretical Chemistry
Inorganic Chemistry
Materials Chemistry

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10.1016/j.ica.2020.119429

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title = "Preparation, structural characterization and cytotoxicity of hydrolytically stable Ti(IV) citrate complexes",

abstract = "Hydrolytically stable and water soluble Ti(IV) complexes can be used for various applications, including industrial, medicinal and more. Herein, a novel tetra-nuclear Ti(IV) complex with citrate ligands was obtained by reacting Ti(IV) isopropoxide and citric acid in an aqueous solution. The three dimensional structure of the complex [Ti4O6(Hcit)3(cit)]9− 1, as it appears in the compound [Co(NH3)6]3[Ti4O6(Hcit)3(cit)]⋅20H2O was determined by single-crystal X-ray crystallography. Complex 1 possesses an adamantane-like {Ti4O6} core where each metal atom is coordinated to a tri-dentate citrate ligand with one dangling CH2COOH group. An additional already known Ti(IV) complex [Ti(Hcit3−)3]5− 2 was synthesized for comparison. The high hydrolytic stability of complexes 1 and 2 has been substantiated based on NMR techniques. The cytotoxicity of the complexes was tested on three cancer cell lines: human ovarian A2780 and drug-resistant variants A2780cis and A2780ADR. Complex 1 showed a slight cytotoxicity towards the ovarian cells, while complex 2 was inactive.",

author = "Nathan Engelberg and Avi Bino and Tshuva, {Edit Y.}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier B.V.",

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doi = "10.1016/j.ica.2020.119429",

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T1 - Preparation, structural characterization and cytotoxicity of hydrolytically stable Ti(IV) citrate complexes

AU - Engelberg, Nathan

AU - Bino, Avi

AU - Tshuva, Edit Y.

PY - 2020/4/1

Y1 - 2020/4/1

N2 - Hydrolytically stable and water soluble Ti(IV) complexes can be used for various applications, including industrial, medicinal and more. Herein, a novel tetra-nuclear Ti(IV) complex with citrate ligands was obtained by reacting Ti(IV) isopropoxide and citric acid in an aqueous solution. The three dimensional structure of the complex [Ti4O6(Hcit)3(cit)]9− 1, as it appears in the compound [Co(NH3)6]3[Ti4O6(Hcit)3(cit)]⋅20H2O was determined by single-crystal X-ray crystallography. Complex 1 possesses an adamantane-like {Ti4O6} core where each metal atom is coordinated to a tri-dentate citrate ligand with one dangling CH2COOH group. An additional already known Ti(IV) complex [Ti(Hcit3−)3]5− 2 was synthesized for comparison. The high hydrolytic stability of complexes 1 and 2 has been substantiated based on NMR techniques. The cytotoxicity of the complexes was tested on three cancer cell lines: human ovarian A2780 and drug-resistant variants A2780cis and A2780ADR. Complex 1 showed a slight cytotoxicity towards the ovarian cells, while complex 2 was inactive.

AB - Hydrolytically stable and water soluble Ti(IV) complexes can be used for various applications, including industrial, medicinal and more. Herein, a novel tetra-nuclear Ti(IV) complex with citrate ligands was obtained by reacting Ti(IV) isopropoxide and citric acid in an aqueous solution. The three dimensional structure of the complex [Ti4O6(Hcit)3(cit)]9− 1, as it appears in the compound [Co(NH3)6]3[Ti4O6(Hcit)3(cit)]⋅20H2O was determined by single-crystal X-ray crystallography. Complex 1 possesses an adamantane-like {Ti4O6} core where each metal atom is coordinated to a tri-dentate citrate ligand with one dangling CH2COOH group. An additional already known Ti(IV) complex [Ti(Hcit3−)3]5− 2 was synthesized for comparison. The high hydrolytic stability of complexes 1 and 2 has been substantiated based on NMR techniques. The cytotoxicity of the complexes was tested on three cancer cell lines: human ovarian A2780 and drug-resistant variants A2780cis and A2780ADR. Complex 1 showed a slight cytotoxicity towards the ovarian cells, while complex 2 was inactive.

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U2 - 10.1016/j.ica.2020.119429

DO - 10.1016/j.ica.2020.119429

M3 - مقالة

SN - 0020-1693

VL - 503

JO - Inorganica Chimica Acta

JF - Inorganica Chimica Acta

M1 - 119429

ER -

Preparation, structural characterization and cytotoxicity of hydrolytically stable Ti(IV) citrate complexes

Abstract

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