Pregnancy and postpartum dynamics revealed by an atlas of millions of lab tests

Alon Bar; Netta Mendelsohn-Cohen; Yael Korem Kohanim; Avi Mayo; Yoel Toledano; Uri Alon

doi:https://doi.org/10.1101/2023.05.11.540359

Pregnancy and postpartum dynamics revealed by an atlas of millions of lab tests

Alon Bar, Netta Mendelsohn-Cohen, Yael Korem Kohanim, Avi Mayo, Yoel Toledano, Uri Alon

Weizmann Institute of Science

Research output: Contribution to journal › Article

Abstract

Pregnancy involves dynamic alterations in most physiological systems. Delivery initiates a transition to postpartum recovery, which similarly exhibits widespread dynamic changes. Physiological dynamics during pregnancy and after delivery have not been systematically analyzed at high temporal resolution in a large human population. Here, we present a dynamic atlas of 78 laboratory tests with weekly time resolution, spanning the period from 20 weeks pre-conception until 80 weeks postpartum, totaling 45 million measurements from over half a million pregnancies. Tests exhibited discontinuities and rebound effects after delivery, and showed extended recovery times of up to a year postpartum. The accuracy of the data revealed effects of preconception supplements and intricate temporal responses to changes in blood volume and renal filtration rate. The dynamical data allowed discrimination between distinct mechanistic models of adaptation in the thyroid axis. These results provide a comprehensive dynamic portrait of the systems physiology of pregnancy.Competing Interest StatementThe authors have declared no competing interest.

Original language	English
Journal	bioRxiv
DOIs	https://doi.org/10.1101/2023.05.11.540359
State	In preparation - 14 May 2023

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@article{11da728474484604be97ee853c613689,

title = "Pregnancy and postpartum dynamics revealed by an atlas of millions of lab tests",

abstract = "Pregnancy involves dynamic alterations in most physiological systems. Delivery initiates a transition to postpartum recovery, which similarly exhibits widespread dynamic changes. Physiological dynamics during pregnancy and after delivery have not been systematically analyzed at high temporal resolution in a large human population. Here, we present a dynamic atlas of 78 laboratory tests with weekly time resolution, spanning the period from 20 weeks pre-conception until 80 weeks postpartum, totaling 45 million measurements from over half a million pregnancies. Tests exhibited discontinuities and rebound effects after delivery, and showed extended recovery times of up to a year postpartum. The accuracy of the data revealed effects of preconception supplements and intricate temporal responses to changes in blood volume and renal filtration rate. The dynamical data allowed discrimination between distinct mechanistic models of adaptation in the thyroid axis. These results provide a comprehensive dynamic portrait of the systems physiology of pregnancy.Competing Interest StatementThe authors have declared no competing interest.",

author = "Alon Bar and Netta Mendelsohn-Cohen and Kohanim, {Yael Korem} and Avi Mayo and Yoel Toledano and Uri Alon",

note = "We thank members of our labs for fruitful discussions. We thank Gabi Barabash and Ran Balicer for the Clalit−Weizmann collaboration. Data acquisition was approved by the Clalit Helsinki Committee RMC-1059-20. Figure 1A and figures 4A, B were made with BioRender (BioRender.com). This work was supported by the European Research Council (ERC) under the European Union{\textquoteright}s Horizon 2020 research and innovation program (Grant Agreement No 856487).",

year = "2023",

month = may,

day = "14",

doi = "https://doi.org/10.1101/2023.05.11.540359",

language = "الإنجليزيّة",

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T1 - Pregnancy and postpartum dynamics revealed by an atlas of millions of lab tests

AU - Bar, Alon

AU - Mendelsohn-Cohen, Netta

AU - Kohanim, Yael Korem

AU - Mayo, Avi

AU - Toledano, Yoel

AU - Alon, Uri

N1 - We thank members of our labs for fruitful discussions. We thank Gabi Barabash and Ran Balicer for the Clalit−Weizmann collaboration. Data acquisition was approved by the Clalit Helsinki Committee RMC-1059-20. Figure 1A and figures 4A, B were made with BioRender (BioRender.com). This work was supported by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (Grant Agreement No 856487).

PY - 2023/5/14

Y1 - 2023/5/14

N2 - Pregnancy involves dynamic alterations in most physiological systems. Delivery initiates a transition to postpartum recovery, which similarly exhibits widespread dynamic changes. Physiological dynamics during pregnancy and after delivery have not been systematically analyzed at high temporal resolution in a large human population. Here, we present a dynamic atlas of 78 laboratory tests with weekly time resolution, spanning the period from 20 weeks pre-conception until 80 weeks postpartum, totaling 45 million measurements from over half a million pregnancies. Tests exhibited discontinuities and rebound effects after delivery, and showed extended recovery times of up to a year postpartum. The accuracy of the data revealed effects of preconception supplements and intricate temporal responses to changes in blood volume and renal filtration rate. The dynamical data allowed discrimination between distinct mechanistic models of adaptation in the thyroid axis. These results provide a comprehensive dynamic portrait of the systems physiology of pregnancy.Competing Interest StatementThe authors have declared no competing interest.

AB - Pregnancy involves dynamic alterations in most physiological systems. Delivery initiates a transition to postpartum recovery, which similarly exhibits widespread dynamic changes. Physiological dynamics during pregnancy and after delivery have not been systematically analyzed at high temporal resolution in a large human population. Here, we present a dynamic atlas of 78 laboratory tests with weekly time resolution, spanning the period from 20 weeks pre-conception until 80 weeks postpartum, totaling 45 million measurements from over half a million pregnancies. Tests exhibited discontinuities and rebound effects after delivery, and showed extended recovery times of up to a year postpartum. The accuracy of the data revealed effects of preconception supplements and intricate temporal responses to changes in blood volume and renal filtration rate. The dynamical data allowed discrimination between distinct mechanistic models of adaptation in the thyroid axis. These results provide a comprehensive dynamic portrait of the systems physiology of pregnancy.Competing Interest StatementThe authors have declared no competing interest.

U2 - https://doi.org/10.1101/2023.05.11.540359

DO - https://doi.org/10.1101/2023.05.11.540359

M3 - مقالة

SN - 2692-8205

JO - bioRxiv

JF - bioRxiv

ER -

Pregnancy and postpartum dynamics revealed by an atlas of millions of lab tests

Abstract

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