Polymeric nanomaterials for islet targeting and immunotherapeutic delivery

Kaustabh Ghosh; Mathumai Kanapathipillai; Netanel Korin; Jason R. McCarthy; Donald E. Ingber

doi:10.1021/nl203334c

Polymeric nanomaterials for islet targeting and immunotherapeutic delivery

Kaustabh Ghosh, Mathumai Kanapathipillai, Netanel Korin, Jason R. McCarthy, Donald E. Ingber

Research output: Contribution to journal › Article › peer-review

Abstract

Here we report a proof-of-concept for development of pancreatic islet-targeting nanoparticles for immunomodulatory therapy of autoimmune type 1 diabetes. Modified with a unique islet-homing peptide, these polymeric nanomaterials exhibit 3-fold greater binding to islet endothelial cells and a 200-fold greater anti-inflammatory effect through targeted islet endothelial cell delivery of an immunosuppressant drug. Our findings also underscore the need to carefully tailor drug loading and nanoparticle dosage to achieve maximal vascular targeting and immunosuppression.

Original language	English
Pages (from-to)	203-208
Number of pages	6
Journal	Nano Letters
Volume	12
Issue number	1
DOIs	https://doi.org/10.1021/nl203334c
State	Published - 11 Jan 2012
Externally published	Yes

Keywords

Diabetes
drug delivery
inflammation
nanoparticle
pancreatic islet
tissue targeting
vascular endothelium

All Science Journal Classification (ASJC) codes

General Chemistry
Condensed Matter Physics
Mechanical Engineering
Bioengineering
General Materials Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/nl203334c

Cite this

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title = "Polymeric nanomaterials for islet targeting and immunotherapeutic delivery",

abstract = "Here we report a proof-of-concept for development of pancreatic islet-targeting nanoparticles for immunomodulatory therapy of autoimmune type 1 diabetes. Modified with a unique islet-homing peptide, these polymeric nanomaterials exhibit 3-fold greater binding to islet endothelial cells and a 200-fold greater anti-inflammatory effect through targeted islet endothelial cell delivery of an immunosuppressant drug. Our findings also underscore the need to carefully tailor drug loading and nanoparticle dosage to achieve maximal vascular targeting and immunosuppression.",

keywords = "Diabetes, drug delivery, inflammation, nanoparticle, pancreatic islet, tissue targeting, vascular endothelium",

author = "Kaustabh Ghosh and Mathumai Kanapathipillai and Netanel Korin and McCarthy, {Jason R.} and Ingber, {Donald E.}",

year = "2012",

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doi = "10.1021/nl203334c",

language = "الإنجليزيّة",

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publisher = "American Chemical Society",

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T1 - Polymeric nanomaterials for islet targeting and immunotherapeutic delivery

AU - Ghosh, Kaustabh

AU - Kanapathipillai, Mathumai

AU - Korin, Netanel

AU - McCarthy, Jason R.

AU - Ingber, Donald E.

PY - 2012/1/11

Y1 - 2012/1/11

N2 - Here we report a proof-of-concept for development of pancreatic islet-targeting nanoparticles for immunomodulatory therapy of autoimmune type 1 diabetes. Modified with a unique islet-homing peptide, these polymeric nanomaterials exhibit 3-fold greater binding to islet endothelial cells and a 200-fold greater anti-inflammatory effect through targeted islet endothelial cell delivery of an immunosuppressant drug. Our findings also underscore the need to carefully tailor drug loading and nanoparticle dosage to achieve maximal vascular targeting and immunosuppression.

AB - Here we report a proof-of-concept for development of pancreatic islet-targeting nanoparticles for immunomodulatory therapy of autoimmune type 1 diabetes. Modified with a unique islet-homing peptide, these polymeric nanomaterials exhibit 3-fold greater binding to islet endothelial cells and a 200-fold greater anti-inflammatory effect through targeted islet endothelial cell delivery of an immunosuppressant drug. Our findings also underscore the need to carefully tailor drug loading and nanoparticle dosage to achieve maximal vascular targeting and immunosuppression.

KW - Diabetes

KW - drug delivery

KW - inflammation

KW - nanoparticle

KW - pancreatic islet

KW - tissue targeting

KW - vascular endothelium

UR - http://www.scopus.com/inward/record.url?scp=84855801394&partnerID=8YFLogxK

U2 - 10.1021/nl203334c

DO - 10.1021/nl203334c

M3 - مقالة

SN - 1530-6984

VL - 12

SP - 203

EP - 208

JO - Nano Letters

JF - Nano Letters

IS - 1

ER -

Polymeric nanomaterials for islet targeting and immunotherapeutic delivery

Abstract

Keywords

All Science Journal Classification (ASJC) codes

UN SDGs

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