Polymeric nanomaterials for islet targeting and immunotherapeutic delivery

Kaustabh Ghosh, Mathumai Kanapathipillai, Netanel Korin, Jason R. McCarthy, Donald E. Ingber

Research output: Contribution to journalArticlepeer-review


Here we report a proof-of-concept for development of pancreatic islet-targeting nanoparticles for immunomodulatory therapy of autoimmune type 1 diabetes. Modified with a unique islet-homing peptide, these polymeric nanomaterials exhibit 3-fold greater binding to islet endothelial cells and a 200-fold greater anti-inflammatory effect through targeted islet endothelial cell delivery of an immunosuppressant drug. Our findings also underscore the need to carefully tailor drug loading and nanoparticle dosage to achieve maximal vascular targeting and immunosuppression.

Original languageEnglish
Pages (from-to)203-208
Number of pages6
JournalNano Letters
Issue number1
StatePublished - 11 Jan 2012
Externally publishedYes


  • Diabetes
  • drug delivery
  • inflammation
  • nanoparticle
  • pancreatic islet
  • tissue targeting
  • vascular endothelium

All Science Journal Classification (ASJC) codes

  • General Chemistry
  • Condensed Matter Physics
  • Mechanical Engineering
  • Bioengineering
  • General Materials Science


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