Polygenic embryo screening: Four clinical considerations warrant further attention

S. Pereira, S. Carmi, G. Altarescu, J. Austin, D. Barlevy, A. Hershlag, E. Juengst, K. Kostick-Quenet, E. Kovanci, R. B. Lathi, M. Mukherjee, I. Van Den Veyver, O. Zuk, G. Lázaro-Muñoz, T. Lencz

Research output: Contribution to journalArticlepeer-review


Recent advances in developing polygenic scores have made it possible to screen embryos for common, complex conditions and traits. Polygenic embryo screening (PES) is currently offered commercially, and though there has been much recent media and academic coverage, reproductive specialists' points of view have not yet been prominent in these discussions. We convened a roundtable of multidisciplinary experts, including reproductive specialists to discuss PES and its implications. In this Opinion, we describe four clinically relevant issues associated with the use of PES that have not yet been discussed in the literature and warrant consideration.

Original languageEnglish
Pages (from-to)1375-1378
Number of pages4
JournalHuman Reproduction
Issue number7
StatePublished - 1 Jul 2022


  • PRS
  • embryo screening
  • genetic screening
  • genomic risk scores
  • polygenic embryo screening
  • polygenic risk scores
  • trait screening

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology
  • Reproductive Medicine


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