Polygenic embryo screening: Four clinical considerations warrant further attention

S. Pereira; S. Carmi; G. Altarescu; J. Austin; D. Barlevy; A. Hershlag; E. Juengst; K. Kostick-Quenet; E. Kovanci; R. B. Lathi; M. Mukherjee; I. Van Den Veyver; O. Zuk; G. Lázaro-Muñoz; T. Lencz

doi:https://doi.org/10.1093/humrep/deac110

Polygenic embryo screening: Four clinical considerations warrant further attention

S. Pereira, S. Carmi, G. Altarescu, J. Austin, D. Barlevy, A. Hershlag, E. Juengst, K. Kostick-Quenet, E. Kovanci, R. B. Lathi, M. Mukherjee, I. Van Den Veyver, O. Zuk, G. Lázaro-Muñoz, T. Lencz

The Hebrew University of Jerusalem

Research output: Contribution to journal › Article › peer-review

Abstract

Recent advances in developing polygenic scores have made it possible to screen embryos for common, complex conditions and traits. Polygenic embryo screening (PES) is currently offered commercially, and though there has been much recent media and academic coverage, reproductive specialists' points of view have not yet been prominent in these discussions. We convened a roundtable of multidisciplinary experts, including reproductive specialists to discuss PES and its implications. In this Opinion, we describe four clinically relevant issues associated with the use of PES that have not yet been discussed in the literature and warrant consideration.

Original language	English
Pages (from-to)	1375-1378
Number of pages	4
Journal	Human Reproduction
Volume	37
Issue number	7
DOIs	https://doi.org/10.1093/humrep/deac110
State	Published - 1 Jul 2022

Keywords

PRS
embryo screening
genetic screening
genomic risk scores
polygenic embryo screening
polygenic risk scores
trait screening

All Science Journal Classification (ASJC) codes

Obstetrics and Gynaecology
Reproductive Medicine

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Pereira, S., Carmi, S., Altarescu, G., Austin, J., Barlevy, D., Hershlag, A., Juengst, E., Kostick-Quenet, K., Kovanci, E., Lathi, R. B., Mukherjee, M., Van Den Veyver, I., Zuk, O., Lázaro-Muñoz, G., & Lencz, T. (2022). Polygenic embryo screening: Four clinical considerations warrant further attention. Human Reproduction, 37(7), 1375-1378. https://doi.org/10.1093/humrep/deac110

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abstract = "Recent advances in developing polygenic scores have made it possible to screen embryos for common, complex conditions and traits. Polygenic embryo screening (PES) is currently offered commercially, and though there has been much recent media and academic coverage, reproductive specialists' points of view have not yet been prominent in these discussions. We convened a roundtable of multidisciplinary experts, including reproductive specialists to discuss PES and its implications. In this Opinion, we describe four clinically relevant issues associated with the use of PES that have not yet been discussed in the literature and warrant consideration.",

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author = "S. Pereira and S. Carmi and G. Altarescu and J. Austin and D. Barlevy and A. Hershlag and E. Juengst and K. Kostick-Quenet and E. Kovanci and Lathi, {R. B.} and M. Mukherjee and {Van Den Veyver}, I. and O. Zuk and G. L{\'a}zaro-Mu{\~n}oz and T. Lencz",

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doi = "https://doi.org/10.1093/humrep/deac110",

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Pereira, S, Carmi, S, Altarescu, G, Austin, J, Barlevy, D, Hershlag, A, Juengst, E, Kostick-Quenet, K, Kovanci, E, Lathi, RB, Mukherjee, M, Van Den Veyver, I, Zuk, O, Lázaro-Muñoz, G & Lencz, T 2022, 'Polygenic embryo screening: Four clinical considerations warrant further attention', Human Reproduction, vol. 37, no. 7, pp. 1375-1378. https://doi.org/10.1093/humrep/deac110

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T2 - Four clinical considerations warrant further attention

AU - Pereira, S.

AU - Carmi, S.

AU - Altarescu, G.

AU - Austin, J.

AU - Barlevy, D.

AU - Hershlag, A.

AU - Juengst, E.

AU - Kostick-Quenet, K.

AU - Kovanci, E.

AU - Lathi, R. B.

AU - Mukherjee, M.

AU - Van Den Veyver, I.

AU - Zuk, O.

AU - Lázaro-Muñoz, G.

AU - Lencz, T.

PY - 2022/7/1

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N2 - Recent advances in developing polygenic scores have made it possible to screen embryos for common, complex conditions and traits. Polygenic embryo screening (PES) is currently offered commercially, and though there has been much recent media and academic coverage, reproductive specialists' points of view have not yet been prominent in these discussions. We convened a roundtable of multidisciplinary experts, including reproductive specialists to discuss PES and its implications. In this Opinion, we describe four clinically relevant issues associated with the use of PES that have not yet been discussed in the literature and warrant consideration.

AB - Recent advances in developing polygenic scores have made it possible to screen embryos for common, complex conditions and traits. Polygenic embryo screening (PES) is currently offered commercially, and though there has been much recent media and academic coverage, reproductive specialists' points of view have not yet been prominent in these discussions. We convened a roundtable of multidisciplinary experts, including reproductive specialists to discuss PES and its implications. In this Opinion, we describe four clinically relevant issues associated with the use of PES that have not yet been discussed in the literature and warrant consideration.

KW - PRS

KW - embryo screening

KW - genetic screening

KW - genomic risk scores

KW - polygenic embryo screening

KW - polygenic risk scores

KW - trait screening

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SN - 0268-1161

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EP - 1378

JO - Human Reproduction

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ER -

Polygenic embryo screening: Four clinical considerations warrant further attention

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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