Poh1 peptidase

Nurit Livnat-Levanon; Fabian Glaser; Michael H. Glickman

doi:10.1016/B978-0-443-28849-4.00288-5

Poh1 peptidase

Nurit Livnat-Levanon
, Fabian Glaser
, Michael H. Glickman

Technion - Israel Institute of Technology

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

The subject of this chapter is Poh1 peptidase. The PSMD14 peptidase is a zinc-dependent metallo-isopeptidase that releases ubiquitin (Ub) from tagged proteins. PSMD14 is a component of the 19S regulatory particle of the 26S proteasome complex. Proteins tagged with Ub are destined for degradation by the proteasome, but the Ub tag has to be removed and the protein unfolded before it can enter through the proteasome pore.

Original language	English
Title of host publication	Handbook of Proteolytic Enzymes
Subtitle of host publication	Metallopeptidases
Publisher	Elsevier
Pages	1813-1823
Number of pages	11
ISBN (Electronic)	9780443288494
ISBN (Print)	9780443288500
DOIs	https://doi.org/10.1016/B978-0-443-28849-4.00288-5
State	Published - 1 Jan 2025

Keywords

DUBs
Deubiquitination
JAMM
MPN
POH1
Rpn11
deubiquitinating enzymes
isopeptidases
mitochondria
proteasome
ubiquitin
zinc metalloprotease

ASJC Scopus subject areas

General Biochemistry,Genetics and Molecular Biology

Access to Document

10.1016/B978-0-443-28849-4.00288-5

Cite this

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keywords = "DUBs, Deubiquitination, JAMM, MPN, POH1, Rpn11, deubiquitinating enzymes, isopeptidases, mitochondria, proteasome, ubiquitin, zinc metalloprotease",

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AU - Glaser, Fabian

AU - Glickman, Michael H.

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AB - The subject of this chapter is Poh1 peptidase. The PSMD14 peptidase is a zinc-dependent metallo-isopeptidase that releases ubiquitin (Ub) from tagged proteins. PSMD14 is a component of the 19S regulatory particle of the 26S proteasome complex. Proteins tagged with Ub are destined for degradation by the proteasome, but the Ub tag has to be removed and the protein unfolded before it can enter through the proteasome pore.

KW - DUBs

KW - Deubiquitination

KW - JAMM

KW - MPN

KW - POH1

KW - Rpn11

KW - deubiquitinating enzymes

KW - isopeptidases

KW - mitochondria

KW - proteasome

KW - ubiquitin

KW - zinc metalloprotease

UR - https://www.scopus.com/pages/publications/105019738158

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DO - 10.1016/B978-0-443-28849-4.00288-5

M3 - Chapter

SN - 9780443288500

SP - 1813

EP - 1823

BT - Handbook of Proteolytic Enzymes

PB - Elsevier

ER -

Poh1 peptidase

Abstract

Keywords

ASJC Scopus subject areas

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