Plasmonic Photothermal Gold Bipyramid Nanoreactors for Ultrafast Real-Time Bioassays

Jung Hoon Lee; Zoya Cheglakov; Jaeseok Yi; Timothy M. Cronin; Kyle J. Gibson; Bozhi Tian; Yossi Weizmann

doi:https://doi.org/10.1021/jacs.7b01779

Plasmonic Photothermal Gold Bipyramid Nanoreactors for Ultrafast Real-Time Bioassays

Jung Hoon Lee, Zoya Cheglakov, Jaeseok Yi, Timothy M. Cronin, Kyle J. Gibson, Bozhi Tian, Yossi Weizmann

Research output: Contribution to journal › Article › peer-review

Abstract

Nucleic acid amplification techniques have been among the most powerful tools for biological and biomedical research, and the vast majority of the bioassays rely on thermocycling that uses time-consuming and expensive Peltier-block heating. Here, we introduce a plasmonic photothermal method for quantitative real-time PCR, using gold bipyramids and light to achieve ultrafast thermocycling. Moreover, we successfully extend our photothermal system to other biological assays, such as isothermal nucleic acid amplification and restriction enzyme digestion.

Original language	American English
Pages (from-to)	8054-8057
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	139
Issue number	24
DOIs	https://doi.org/10.1021/jacs.7b01779
State	Published - 21 Jun 2017
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Chemistry
Biochemistry
Catalysis
Colloid and Surface Chemistry

Access to Document

https://doi.org/10.1021/jacs.7b01779

Cite this

@article{806ed48d83c7423d910964e0fedd00f3,

title = "Plasmonic Photothermal Gold Bipyramid Nanoreactors for Ultrafast Real-Time Bioassays",

abstract = "Nucleic acid amplification techniques have been among the most powerful tools for biological and biomedical research, and the vast majority of the bioassays rely on thermocycling that uses time-consuming and expensive Peltier-block heating. Here, we introduce a plasmonic photothermal method for quantitative real-time PCR, using gold bipyramids and light to achieve ultrafast thermocycling. Moreover, we successfully extend our photothermal system to other biological assays, such as isothermal nucleic acid amplification and restriction enzyme digestion.",

author = "Lee, {Jung Hoon} and Zoya Cheglakov and Jaeseok Yi and Cronin, {Timothy M.} and Gibson, {Kyle J.} and Bozhi Tian and Yossi Weizmann",

note = "Publisher Copyright: {\textcopyright} 2017 American Chemical Society.",

year = "2017",

month = jun,

day = "21",

doi = "https://doi.org/10.1021/jacs.7b01779",

language = "American English",

volume = "139",

pages = "8054--8057",

journal = "Journal of the American Chemical Society",

issn = "0002-7863",

publisher = "American Chemical Society",

number = "24",

}

TY - JOUR

T1 - Plasmonic Photothermal Gold Bipyramid Nanoreactors for Ultrafast Real-Time Bioassays

AU - Lee, Jung Hoon

AU - Cheglakov, Zoya

AU - Yi, Jaeseok

AU - Cronin, Timothy M.

AU - Gibson, Kyle J.

AU - Tian, Bozhi

AU - Weizmann, Yossi

PY - 2017/6/21

Y1 - 2017/6/21

N2 - Nucleic acid amplification techniques have been among the most powerful tools for biological and biomedical research, and the vast majority of the bioassays rely on thermocycling that uses time-consuming and expensive Peltier-block heating. Here, we introduce a plasmonic photothermal method for quantitative real-time PCR, using gold bipyramids and light to achieve ultrafast thermocycling. Moreover, we successfully extend our photothermal system to other biological assays, such as isothermal nucleic acid amplification and restriction enzyme digestion.

AB - Nucleic acid amplification techniques have been among the most powerful tools for biological and biomedical research, and the vast majority of the bioassays rely on thermocycling that uses time-consuming and expensive Peltier-block heating. Here, we introduce a plasmonic photothermal method for quantitative real-time PCR, using gold bipyramids and light to achieve ultrafast thermocycling. Moreover, we successfully extend our photothermal system to other biological assays, such as isothermal nucleic acid amplification and restriction enzyme digestion.

UR - http://www.scopus.com/inward/record.url?scp=85021126621&partnerID=8YFLogxK

U2 - https://doi.org/10.1021/jacs.7b01779

DO - https://doi.org/10.1021/jacs.7b01779

M3 - Article

C2 - 28457135

SN - 0002-7863

VL - 139

SP - 8054

EP - 8057

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 24

ER -

Plasmonic Photothermal Gold Bipyramid Nanoreactors for Ultrafast Real-Time Bioassays

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this