TY - JOUR
T1 - Plant histone htb (H2b) variants in regulating chromatin structure and function
AU - Khadka, Janardan
AU - Pesok, Anat
AU - Grafi, Gideon
N1 - Funding Information: This research was supported by the Israel Science Foundation research grant to GG, grant number 667/19. Funding Information: This research was supported by the Israel Science Foundation research grant to GG, grant number Publisher Copyright: © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2020/11/1
Y1 - 2020/11/1
N2 - Besides chemical modification of histone proteins, chromatin dynamics can be modulated by histone variants. Most organisms possess multiple genes encoding for core histone proteins, which are highly similar in amino acid sequence. The Arabidopsis thaliana genome contains 11 genes encoding for histone H2B (HTBs), 13 for H2A (HTAs), 15 for H3 (HTRs), and 8 genes encoding for histone H4 (HFOs). The finding that histone variants may be expressed in specific tissues and/or during specific developmental stages, often displaying specific nuclear localization and involvement in specific nuclear processes suggests that histone variants have evolved to carry out specific functions in regulating chromatin structure and function and might be important for better understanding of growth and development and particularly the response to stress. In this review, we will elaborate on a group of core histone proteins in Arabidopsis, namely histone H2B, summarize existing data, and illuminate the potential function of H2B variants in regulating chromatin structure and function in Arabidopsis thaliana.
AB - Besides chemical modification of histone proteins, chromatin dynamics can be modulated by histone variants. Most organisms possess multiple genes encoding for core histone proteins, which are highly similar in amino acid sequence. The Arabidopsis thaliana genome contains 11 genes encoding for histone H2B (HTBs), 13 for H2A (HTAs), 15 for H3 (HTRs), and 8 genes encoding for histone H4 (HFOs). The finding that histone variants may be expressed in specific tissues and/or during specific developmental stages, often displaying specific nuclear localization and involvement in specific nuclear processes suggests that histone variants have evolved to carry out specific functions in regulating chromatin structure and function and might be important for better understanding of growth and development and particularly the response to stress. In this review, we will elaborate on a group of core histone proteins in Arabidopsis, namely histone H2B, summarize existing data, and illuminate the potential function of H2B variants in regulating chromatin structure and function in Arabidopsis thaliana.
KW - Arabidopsis
KW - Chromatin organization
KW - Flowering
KW - Histone H2B (HTB) variants
KW - Histone fold
KW - Histone modification
KW - Nuclear localization
KW - Nucleolar retention
KW - Nucleosome
UR - http://www.scopus.com/inward/record.url?scp=85094143022&partnerID=8YFLogxK
U2 - https://doi.org/10.3390/plants9111435
DO - https://doi.org/10.3390/plants9111435
M3 - Review article
C2 - 33113795
SN - 2223-7747
VL - 9
SP - 1
EP - 14
JO - Plants
JF - Plants
IS - 11
M1 - 1435
ER -