Physical properties of gold nanoparticles affect skin penetration via hair follicles

Nethanel Friedman, Arie Dagan, Jhonathan Elia, Sharon Merims, Ofra Benny

Research output: Contribution to journalArticlepeer-review

Abstract

Drug penetration through the skin is significant for both transdermal and dermal delivery. One mechanism that has attracted attention over the last two decades is the transport pathway of nanoparticles via hair follicle, through the epidermis, directly to the pilosebaceous unit and blood vessels. Studies demonstrate that particle size is an important factor for drug penetration. However, in order to gain more information for the purpose of improving this mode of drug delivery, a thorough understanding of the optimal physical particle properties is needed. In this study, we fabricated fluorescently labeled gold nanoparticles (GNP) with a tight control over the size and shape. The effect of the particles' physical parameters on follicular penetration was evaluated histologically. We used horizontal human skin sections and found that the optimal size for polymeric particles is 0.25 μm. In addition, shape penetration experiments revealed gold nanostars' superiority over spherical particles. Our findings suggest the importance of the particles' physical properties in the design of nanocarriers delivered to the pilosebaceous unit.

Original languageAmerican English
Article number102414
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume36
DOIs
StatePublished - Aug 2021

Keywords

  • Au nanoparticle
  • Dermal delivery
  • Gold nanoparticles
  • Hair follicle

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Molecular Medicine
  • Biomedical Engineering
  • General Materials Science
  • Medicine (miscellaneous)
  • Pharmaceutical Science

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