Photonic Si microwell architectures for rapid antifungal susceptibility determination of Candida auris

Christopher Heuer; Xin Jiang; Gali Ron; Orna Ternyak; Thomas Scheper; Janina Bahnemann; Ester Segal

doi:10.1039/d3cc04446g

Photonic Si microwell architectures for rapid antifungal susceptibility determination of Candida auris

Christopher Heuer, Xin Jiang, Gali Ron, Orna Ternyak, Thomas Scheper, Janina Bahnemann, Ester Segal

Technion - Israel Institute of Technology

Research output: Contribution to journal › Article › peer-review

Abstract

We present the application of a photonic silicon chip-based optical sensor system for expeditious and phenotypic antifungal susceptibility testing. This label-free diagnostic assay optically monitors the growth of Candida auris at varying antifungal concentrations on a microwell-structured silicon chip in real-time, and antifungal susceptibility is detected within 6 h, four times faster than in the current gold standard method.

Original language	English
Pages (from-to)	1305-1308
Number of pages	4
Journal	Chemical Communications
Volume	60
Issue number	10
DOIs	https://doi.org/10.1039/d3cc04446g
State	Published - 27 Dec 2023

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
General Chemistry
Ceramics and Composites
Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
Catalysis

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10.1039/d3cc04446g

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title = "Photonic Si microwell architectures for rapid antifungal susceptibility determination of Candida auris",

abstract = "We present the application of a photonic silicon chip-based optical sensor system for expeditious and phenotypic antifungal susceptibility testing. This label-free diagnostic assay optically monitors the growth of Candida auris at varying antifungal concentrations on a microwell-structured silicon chip in real-time, and antifungal susceptibility is detected within 6 h, four times faster than in the current gold standard method.",

author = "Christopher Heuer and Xin Jiang and Gali Ron and Orna Ternyak and Thomas Scheper and Janina Bahnemann and Ester Segal",

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T1 - Photonic Si microwell architectures for rapid antifungal susceptibility determination of Candida auris

AU - Heuer, Christopher

AU - Jiang, Xin

AU - Ron, Gali

AU - Ternyak, Orna

AU - Scheper, Thomas

AU - Bahnemann, Janina

AU - Segal, Ester

PY - 2023/12/27

Y1 - 2023/12/27

N2 - We present the application of a photonic silicon chip-based optical sensor system for expeditious and phenotypic antifungal susceptibility testing. This label-free diagnostic assay optically monitors the growth of Candida auris at varying antifungal concentrations on a microwell-structured silicon chip in real-time, and antifungal susceptibility is detected within 6 h, four times faster than in the current gold standard method.

AB - We present the application of a photonic silicon chip-based optical sensor system for expeditious and phenotypic antifungal susceptibility testing. This label-free diagnostic assay optically monitors the growth of Candida auris at varying antifungal concentrations on a microwell-structured silicon chip in real-time, and antifungal susceptibility is detected within 6 h, four times faster than in the current gold standard method.

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U2 - 10.1039/d3cc04446g

DO - 10.1039/d3cc04446g

M3 - مقالة

C2 - 38197155

SN - 1359-7345

VL - 60

SP - 1305

EP - 1308

JO - Chemical Communications

JF - Chemical Communications

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ER -

Photonic Si microwell architectures for rapid antifungal susceptibility determination of Candida auris

Abstract

All Science Journal Classification (ASJC) codes

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