Photodynamic effect of novel hexa-iodinated quinono-cyanine dye on Staphylococcus aureus

Maksym Bokan, Faina Nakonechny, Efrosiniia Talalai, Dmytro Kobzev, Gary Gellerman, Leonid Patsenker

Research output: Contribution to journalArticlepeer-review


Background: Staphylococcus aureus (S. aureus) is a Gram-positive bacteria and major human pathogen which can cause a wide variety of serious infections when it enters the bloodstream or internal tissues. Antimicrobial photodynamic therapy (APDT) utilizing a light-activated dye (photosensitizer) is a powerful method for in vitro and in vivo eradication of S. aureus and other pathogenic bacteria. However, the development of highly efficient, long-wavelength photosensitizers showing high phototoxicity to pathogens and low dark toxicity is still challenging. Aim: To develop a highly efficient, long-wavelength photosensitizer for photodynamic inactivation of S. aureus. Method: Synthesis of the new photosensitizer, hexa-iodinated quinono-cyanine dye IQCy and investigation of the dark and light-induced toxicity of this dye compared to known photosensitizers Chlorin e6 (Ce6) and HITC towards S. aureus. Results: When exposed to 14.9 J/cm2 white LED light, 0.5 μM of IQCy, Ce6 and HITC inactivate, respectively, 99 %, 40 % and 30 % of S. aureus and at 0.05 μM and 27.9 J/cm2 — 71 %, 18 % and 9%, which is much better compared to Ce6 and HITC. IQCy exhibits no dark toxicity at least at 10 μM dye concentration. Conclusions: IQCy demonstrates a more pronounced photodynamic inactivation of S. aureus as compared to Ce6 and HITC and can be employed for the eradication of these bacteria at lower concentration and reduced light dose.

Original languageEnglish
Article number101866
JournalPhotodiagnosis and Photodynamic Therapy
StatePublished - Sep 2020


  • Antimicrobial photodynamic therapy
  • Iodinated quinono-cyanine
  • Photosensitizer
  • Staphylococcus aureus

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Oncology
  • Dermatology
  • Pharmacology (medical)


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